prikaz prve stranice dokumenta Frequency of BRAF Mutations in Dysplastic Nevi, Lentigo Maligna, and Melanoma In Situ
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Frequency of BRAF Mutations in Dysplastic Nevi, Lentigo Maligna, and Melanoma In Situ
Journal of Clinical Medicine, 13 (2024), 16; 4799. https://doi.org/10.3390/jcm13164799
Prkačin, Ivana; Šamija, Ivan; Filipović, Nika; Vucić, Matej; Vučić, Majda; Ferara, Nikola; Šitum, Mirna

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Prkačin, I., Šamija, I., Filipović, N., Vucić, M., Vučić, M., Ferara, N. i Šitum, M. (2024). Frequency of BRAF Mutations in Dysplastic Nevi, Lentigo Maligna, and Melanoma In Situ. Journal of Clinical Medicine, 13. (16). doi: 10.3390/jcm13164799

Prkačin, Ivana, et al. "Frequency of BRAF Mutations in Dysplastic Nevi, Lentigo Maligna, and Melanoma In Situ." Journal of Clinical Medicine, vol. 13, br. 16, 2024. https://doi.org/10.3390/jcm13164799

Prkačin, Ivana, Ivan Šamija, Nika Filipović, Matej Vucić, Majda Vučić, Nikola Ferara i Mirna Šitum. "Frequency of BRAF Mutations in Dysplastic Nevi, Lentigo Maligna, and Melanoma In Situ." Journal of Clinical Medicine 13, br. 16 (2024). https://doi.org/10.3390/jcm13164799

Prkačin, I., et al. (2024) 'Frequency of BRAF Mutations in Dysplastic Nevi, Lentigo Maligna, and Melanoma In Situ', Journal of Clinical Medicine, 13(16). doi: 10.3390/jcm13164799

Prkačin I, Šamija I, Filipović N, Vucić M, Vučić M, Ferara N, i sur.. Frequency of BRAF Mutations in Dysplastic Nevi, Lentigo Maligna, and Melanoma In Situ. Journal of Clinical Medicine [Internet]. 15.08.2024. [pristupljeno 13.04.2025.];13(16). doi: 10.3390/jcm13164799

I. Prkačin, et al., "Frequency of BRAF Mutations in Dysplastic Nevi, Lentigo Maligna, and Melanoma In Situ", Journal of Clinical Medicine, vol. 13, br. 16, Kolovoz 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:520392. [Citirano: 13.04.2025.]

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Podaci o radu
Naslov (engleski)Frequency of BRAF Mutations in Dysplastic Nevi, Lentigo Maligna, and Melanoma In Situ
AutorIvana Prkačin
AutorIvan Šamija
AutorNika Filipović
AutorMatej Vucić
AutorMajda Vučić
AutorNikola Ferara
AutorMirna Šitum
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Background: In melanomas, mutations in the BRAF gene are common and their occurrence represents an early oncogenic event. Our goal was to determine and compare the frequency of BRAF gene mutations in dysplastic nevi (ND) and melanomas in situ (MIS), as well as whether there is a correlation between the presence of BRAF gene mutations and various anamnestic, clinical, and histopathologic variables. Methods: A total of 175 patients—106 with ND, 41 with MIS, and 28 with lentigo maligna (LM) were included in the study. DNA was extracted from tissue samples and analyzed using the competitive allele-specific TaqMan chain reaction by polymerase in real time to detect the presence of BRAF V600E and V600K mutations. The data were compared with anamnestic, clinical, and histopathological data. Results: There is a statistically significant correlation between the presence of BRAF mutation and the diagnosis of melanoma in situ (χ2 test, χ2 = 29.17, p < 0.0001). Patients with LM had a significantly lower incidence of BRAF mutations compared to patients with ND and MIS. There was a significant correlation between the presence of a BRAF mutation and tumor localization, as well as the age of the patient, but no statistically significant correlation between the presence of a BRAF mutation and sex, tumor size, or previous melanoma diagnosis. Conclusions: BRAF mutations in ND are essentially required; however, they are an insufficient oncogenic trigger for the development of melanoma. This research contributes to a better understanding of the etiopathogenesis of melanoma and the role of ND as possible precursor lesions.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Clinical Medicine
Brojčani podacivol. 13, br. 16, 4799
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm13164799
URN:NBNurn:nbn:hr:127:520392
Datum objave publikacije2024-08-15
URL dokumentahttps://www.mdpi.com/2077-0383/13/16/4799
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-06 09:58:20