Salivary interleukin‐6 and tumor necrosis factor‐ α in patients with recurrent aphthous ulceration

Znanstveni rad - Izvorni znanstveni rad

• Autor: V. Vučićević Boras
• Autor: J. Lukač
• Autor: V. Brailo
• Autor: P. Picek
• Autor: D. Kordić
• Autor: Iva Alajbeg
• Autorova ustanova: Sveučilište u Zagrebu; Stomatološki fakultet
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Dentalna medicina

Sažetak (engleski)

Background: Recurrent apthous ulceration (RAU) is a well known oral disease which seems to be mediated principally by the immune system. However, it is still a matter of debate which part of the immune system is implicated in its pathogenesis as a reaction to the still unknown antigen. The aim of this study was to evaluate salivary cytokines, interleukin (IL)-6, and tumor necrosis factor (TNF)-α. Methods: In 26 patients with minor RAU, age range of 23-49 years (mean 27.3 years), during both the acute phase and remission and in 26 healthy controls, age range of 22-64 years (mean 30.1 years), salivary IL-6 and TNF-α levels were determined by use of enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed by use of descriptive statistics. Results: Significant differences in salivary TNF-α between healthy controls and patients with acute RAU and during the remission period were found (P < 0.001) as well as between patients with acute RAU and those during the remission period (P < 0.001). No differences in salivary IL-6 between all three groups could be found. Conclusions: We might conclude that elevated salivary TNF-α levels during acute RAU and especially during the remission period are of importance in RAU, whereas salivary IL-6 levels seem not to play a role in the RAU disease.

• Ključne riječi (engleski): Recurrent aphthous; Salivary cytokines; Ulceration
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - međunarodna recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Journal of Oral Pathology & Medicine
• Brojčani podaci: vol. 35, br. 4, str. 241-243
• p-ISSN: 0904-2512
• e-ISSN: 1600-0714
• DOI: https://doi.org/10.1111/j.1600-0714.2006.00404.x
• URN:NBN: urn:nbn:hr:127:716793
• Datum objave publikacije: 2006-03-03
• URL dokumenta: https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0714.2006.00404.x
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-10-31 11:21:17