Salivary interleukin‐6 and tumor necrosis factor‐ α in patients with recurrent aphthous ulceration

Scientific paper - Original scientific paper

• Author: V. Vučićević Boras
• Author: J. Lukač
• Author: V. Brailo
• Author: P. Picek
• Author: D. Kordić
• Author: Iva Alajbeg
• Author's institution: University of Zagreb; School of Dental Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine

Abstract (english)

Background: Recurrent apthous ulceration (RAU) is a well known oral disease which seems to be mediated principally by the immune system. However, it is still a matter of debate which part of the immune system is implicated in its pathogenesis as a reaction to the still unknown antigen. The aim of this study was to evaluate salivary cytokines, interleukin (IL)-6, and tumor necrosis factor (TNF)-α. Methods: In 26 patients with minor RAU, age range of 23-49 years (mean 27.3 years), during both the acute phase and remission and in 26 healthy controls, age range of 22-64 years (mean 30.1 years), salivary IL-6 and TNF-α levels were determined by use of enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed by use of descriptive statistics. Results: Significant differences in salivary TNF-α between healthy controls and patients with acute RAU and during the remission period were found (P < 0.001) as well as between patients with acute RAU and those during the remission period (P < 0.001). No differences in salivary IL-6 between all three groups could be found. Conclusions: We might conclude that elevated salivary TNF-α levels during acute RAU and especially during the remission period are of importance in RAU, whereas salivary IL-6 levels seem not to play a role in the RAU disease.

• Keywords (english): Recurrent aphthous; Salivary cytokines; Ulceration
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review - international
• Publication version: Published version
• Journal title: Journal of Oral Pathology & Medicine
• Numbering: vol. 35, no. 4, pp. 241-243
• p-ISSN: 0904-2512
• e-ISSN: 1600-0714
• DOI: https://doi.org/10.1111/j.1600-0714.2006.00404.x
• URN:NBN: urn:nbn:hr:127:716793
• Publication: 2006-03-03
• Document URL: https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0714.2006.00404.x
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-10-31 11:21:17