prikaz prve stranice dokumenta Results of Treating Mild to Moderate Knee Osteoarthritis with Autologous Conditioned Adipose Tissue and Leukocyte-Poor Platelet-Rich Plasma
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Results of Treating Mild to Moderate Knee Osteoarthritis with Autologous Conditioned Adipose Tissue and Leukocyte-Poor Platelet-Rich Plasma
Journal of Personalized Medicine, 13 (2022), 1; 47. https://doi.org/10.3390/jpm13010047
Molnar, Vilim; Pavelić, Eduard; Jeleč, Željko; Brlek, Petar; Matišić, Vid; Borić, Igor; Hudetz, Damir; Rod, Eduard; Vidović, Dinko; Starčević, Neven; Čemerin, Martin; Karli, David C.; Primorac, Dragan

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Molnar, V., Pavelić, E., Jeleč, Ž., Brlek, P., Matišić, V., Borić, I. ... Primorac, D. (2022). Results of Treating Mild to Moderate Knee Osteoarthritis with Autologous Conditioned Adipose Tissue and Leukocyte-Poor Platelet-Rich Plasma. Journal of Personalized Medicine, 13. (1). doi: 10.3390/jpm13010047

Molnar, Vilim, et al. "Results of Treating Mild to Moderate Knee Osteoarthritis with Autologous Conditioned Adipose Tissue and Leukocyte-Poor Platelet-Rich Plasma." Journal of Personalized Medicine, vol. 13, br. 1, 2022. https://doi.org/10.3390/jpm13010047

Molnar, Vilim, Eduard Pavelić, Željko Jeleč, Petar Brlek, Vid Matišić, Igor Borić, Damir Hudetz, et al. "Results of Treating Mild to Moderate Knee Osteoarthritis with Autologous Conditioned Adipose Tissue and Leukocyte-Poor Platelet-Rich Plasma." Journal of Personalized Medicine 13, br. 1 (2022). https://doi.org/10.3390/jpm13010047

Molnar, V., et al. (2022) 'Results of Treating Mild to Moderate Knee Osteoarthritis with Autologous Conditioned Adipose Tissue and Leukocyte-Poor Platelet-Rich Plasma', Journal of Personalized Medicine, 13(1). doi: 10.3390/jpm13010047

Molnar V, Pavelić E, Jeleč Ž, Brlek P, Matišić V, Borić I, i sur.. Results of Treating Mild to Moderate Knee Osteoarthritis with Autologous Conditioned Adipose Tissue and Leukocyte-Poor Platelet-Rich Plasma. Journal of Personalized Medicine [Internet]. 26.12.2022. [pristupljeno 27.11.2024.];13(1). doi: 10.3390/jpm13010047

V. Molnar, et al., "Results of Treating Mild to Moderate Knee Osteoarthritis with Autologous Conditioned Adipose Tissue and Leukocyte-Poor Platelet-Rich Plasma", Journal of Personalized Medicine, vol. 13, br. 1, Prosinac 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:943932. [Citirano: 27.11.2024.]

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Naslov (engleski)Results of Treating Mild to Moderate Knee Osteoarthritis with Autologous Conditioned Adipose Tissue and Leukocyte-Poor Platelet-Rich Plasma
AutorVilim Molnar
MBZ: 32165
AutorEduard Pavelić
AutorŽeljko Jeleč
AutorPetar Brlek
AutorVid Matišić
AutorIgor Borić
AutorDamir Hudetz
AutorEduard Rod
AutorDinko Vidović
AutorNeven Starčević
AutorMartin Čemerin
AutorDavid C. Karli
AutorDragan Primorac
Autorova ustanova(Klinička bolnica Sv. Duh)
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet Osijek
Autorova ustanovaSveučilište u Splitu
Medicinski fakultet
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Knee osteoarthritis (KOA) is one of the most common musculoskeletal disorders. Much progress has been made in regenerative medicine for the symptomatic treatment of KOA, including products containing stromal vascular fraction (SVF) and platelet-rich plasma (PRP). The aim of this study was to evaluate clinical and radiological findings after the application of autologous conditioned adipose tissue (ACA) and leukocyte-poor PRP (LP-PRP) in patients with mild to moderate KOA. A total of 16 patients (eight male and eight female) with changes related to KOA on the magnetic resonance imaging (MRI), but without severe osteophytosis, full-thickness cartilage loss, or subchondral bone involvement were included in this study. Patients received an intraarticular, ultrasound-guided injection of ACA and LP-PRP. Clinical scores, including a visual analog scale for pain (VAS), Knee Injury and Osteoarthritis Outcome Score (KOOS), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were evaluated at baseline and at the three and six month follow-ups showing a statistically significant improvements at three and six months post-intervention. Furthermore, the delayed gadolinium-enhanced MRI of the cartilage (dGEMRIC) indices were evaluated at baseline and at the three and six month follow-ups showing no significant changes after treatment with ACA and LP-PRP, which were actually equal to the dGEMRIC indices measured in the control group (hyaluronic acid applied in contralateral knees without osteoarthritis). ACA with LP-PRP presents a viable minimally invasive therapeutic option for the clinical improvement of mild to moderate KOA. However, MFAT produced by different systems is likely to differ in cellular content, which can directly affect the paracrine effect (cytokine secretion) of mesenchymal stem cells and consequently the regeneration process.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Personalized Medicine
Brojčani podacivol. 13, br. 1, 47
e-ISSN2075-4426
DOIhttps://doi.org/10.3390/jpm13010047
URN:NBNurn:nbn:hr:127:943932
Datum objave publikacije2022-12-26
URL dokumentahttps://www.mdpi.com/2075-4426/13/1/47
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-03-03 09:21:21