prikaz prve stranice dokumenta Results of Treating Mild to Moderate Knee Osteoarthritis with Autologous Conditioned Adipose Tissue and Leukocyte-Poor Platelet-Rich Plasma
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Scientific paper - Original scientific paper
Results of Treating Mild to Moderate Knee Osteoarthritis with Autologous Conditioned Adipose Tissue and Leukocyte-Poor Platelet-Rich Plasma
Journal of Personalized Medicine, 13 (2022), 1; 47. https://doi.org/10.3390/jpm13010047
Molnar, Vilim; Pavelić, Eduard; Jeleč, Željko; Brlek, Petar; Matišić, Vid; Borić, Igor; Hudetz, Damir; Rod, Eduard; Vidović, Dinko; Starčević, Neven; Čemerin, Martin; Karli, David C.; Primorac, Dragan

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Molnar, V., Pavelić, E., Jeleč, Ž., Brlek, P., Matišić, V., Borić, I. ... Primorac, D. (2022). Results of Treating Mild to Moderate Knee Osteoarthritis with Autologous Conditioned Adipose Tissue and Leukocyte-Poor Platelet-Rich Plasma. Journal of Personalized Medicine, 13. (1). doi: 10.3390/jpm13010047

Molnar, Vilim, et al. "Results of Treating Mild to Moderate Knee Osteoarthritis with Autologous Conditioned Adipose Tissue and Leukocyte-Poor Platelet-Rich Plasma." Journal of Personalized Medicine, vol. 13, no. 1, 2022. https://doi.org/10.3390/jpm13010047

Molnar, Vilim, Eduard Pavelić, Željko Jeleč, Petar Brlek, Vid Matišić, Igor Borić, Damir Hudetz, et al. "Results of Treating Mild to Moderate Knee Osteoarthritis with Autologous Conditioned Adipose Tissue and Leukocyte-Poor Platelet-Rich Plasma." Journal of Personalized Medicine 13, no. 1 (2022). https://doi.org/10.3390/jpm13010047

Molnar, V., et al. (2022) 'Results of Treating Mild to Moderate Knee Osteoarthritis with Autologous Conditioned Adipose Tissue and Leukocyte-Poor Platelet-Rich Plasma', Journal of Personalized Medicine, 13(1). doi: 10.3390/jpm13010047

Molnar V, Pavelić E, Jeleč Ž, Brlek P, Matišić V, Borić I, and sur.. Results of Treating Mild to Moderate Knee Osteoarthritis with Autologous Conditioned Adipose Tissue and Leukocyte-Poor Platelet-Rich Plasma. Journal of Personalized Medicine [Internet]. 2022 December 26 [cited 2024 December 04];13(1). doi: 10.3390/jpm13010047

V. Molnar, et al., "Results of Treating Mild to Moderate Knee Osteoarthritis with Autologous Conditioned Adipose Tissue and Leukocyte-Poor Platelet-Rich Plasma", Journal of Personalized Medicine, vol. 13, no. 1, December 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:943932. [Accessed: 04 December 2024]

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Metadata
Title (english)Results of Treating Mild to Moderate Knee Osteoarthritis with Autologous Conditioned Adipose Tissue and Leukocyte-Poor Platelet-Rich Plasma
AuthorVilim Molnar
MBZ: 32165
AuthorEduard Pavelić
AuthorŽeljko Jeleč
AuthorPetar Brlek
AuthorVid Matišić
AuthorIgor Borić
AuthorDamir Hudetz
AuthorEduard Rod
AuthorDinko Vidović
AuthorNeven Starčević
AuthorMartin Čemerin
AuthorDavid C. Karli
AuthorDragan Primorac
Author's institution(Sv. Duh University Hospital)
Author's institution(Sestre milosrdnice University Hospital Center)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Author's institutionUniversity of Split
School of Medicine
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Knee osteoarthritis (KOA) is one of the most common musculoskeletal disorders. Much progress has been made in regenerative medicine for the symptomatic treatment of KOA, including products containing stromal vascular fraction (SVF) and platelet-rich plasma (PRP). The aim of this study was to evaluate clinical and radiological findings after the application of autologous conditioned adipose tissue (ACA) and leukocyte-poor PRP (LP-PRP) in patients with mild to moderate KOA. A total of 16 patients (eight male and eight female) with changes related to KOA on the magnetic resonance imaging (MRI), but without severe osteophytosis, full-thickness cartilage loss, or subchondral bone involvement were included in this study. Patients received an intraarticular, ultrasound-guided injection of ACA and LP-PRP. Clinical scores, including a visual analog scale for pain (VAS), Knee Injury and Osteoarthritis Outcome Score (KOOS), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were evaluated at baseline and at the three and six month follow-ups showing a statistically significant improvements at three and six months post-intervention. Furthermore, the delayed gadolinium-enhanced MRI of the cartilage (dGEMRIC) indices were evaluated at baseline and at the three and six month follow-ups showing no significant changes after treatment with ACA and LP-PRP, which were actually equal to the dGEMRIC indices measured in the control group (hyaluronic acid applied in contralateral knees without osteoarthritis). ACA with LP-PRP presents a viable minimally invasive therapeutic option for the clinical improvement of mild to moderate KOA. However, MFAT produced by different systems is likely to differ in cellular content, which can directly affect the paracrine effect (cytokine secretion) of mesenchymal stem cells and consequently the regeneration process.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Personalized Medicine
Numberingvol. 13, no. 1, 47
e-ISSN2075-4426
DOIhttps://doi.org/10.3390/jpm13010047
URN:NBNurn:nbn:hr:127:943932
Publication2022-12-26
Document URLhttps://www.mdpi.com/2075-4426/13/1/47
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-03-03 09:21:21