Proteomska istraživanja parodontnih bolesti

professional thesis

• Title (english): Proteomic studies of periodontal diseases
• Author: Ana Badovinac
• Mentor: Darije Plančak (mentor)
• Committee member: Darko Božić (predsjednik povjerenstva)
• Committee member: Darije Plančak (član povjerenstva)
• Committee member: Andrej Aurer (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Department of Periodontology); Zagreb
• Defense date and country: 2015-12-22, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Periodontology

Abstract

Parodontne bolesti variraju od relativno benignih oblika bolesti potpornog zubnog tkiva poznatijih pod nazivom gingivitis, pa sve do agresivnog i kroničnog parodontitsa, koji ne da su samo prijetnja denticiji, već mogu biti prijetnja cjelokupnom zdravlju organizma. Tijekom posljednjeg desetljeća potraga za biomarkerima parodontnih bolesti postaje sve zanimljivija. Traže se specifični biomarkeri koji bi bili važni za dijagnosticiranje, prognozu i praćenje bolesti, ali i za odgovor pacijenta na terapiju.
Proteomske analize imaju sve veću primjenu u identifikaciji proteina kod pacijenata s parodontnim bolestima, a svoje mjesto također pronalaze i u istraživanjima koja se bave otkrivanjima mogućih biomarkera. Proteini su potencijalno velik izvor mogućih biomarkera budući da su upravo oni molekule koje povezuju statični genom pojedinca i biološku aktivnost organizma. Rezultati proteomskih istraživanja parodontnih bolesti pokazuju širok spektar proteina koji bi mogli pridonijeti razumijevanju patoloških promjena koje se događaju tijekom bolesti. Među mnogim zanimljivim proteinima ističu se aneksini, S-100 i 14-3-3- proteini, matriksne metaloproteinaze i lipoproteini. Uz navedene proteine, po svojoj funkciji i ponašanju u parodontnim bolestima ističu se i druga imena, no jednako kao i za navedene proteine potrebna su daljnja istraživanja s većim brojem uzoraka za eventualno definiranje i izdvajanje biomarkera parodontnih bolesti.

Abstract (english)

Periodontal diseases range from the relatively benign form of the disease known as gingivitis, to the chronic and aggressive periodontitis, which are not only a threat to the dentition, but also a threat to the overall health. During the last decade the search for the biomarkers of periodontal diseases becomes more and more interesting. We are looking for specific biomarkers that would be important for the diagnosis, prognosis and monitoring of diseases, but also for the patient's response to the therapy.
Proteomic analyses have been increasingly used in the identification of proteins in patients with periodontal diseases, and have also found their place in the research dealing with the detection of possible biomarkers. Proteins are a potentially large source of biomarkers since they are the molecules that connect the static genome of the individual and the biological activity of the organism. Results of the proteomic studies of periodontal diseases show a wide range of proteins that could contribute to the better understanding of pathological changes that occur during disease. Among the most interesting proteins stand the annexins, S-100 and 14-3-3 proteins, lipoproteins and matrix metalloproteinase. In addition to these proteins, according to their function and behaviour, there are also many other interesting names, but the problem is the same. Further research with a larger number of samples is required for the possible designation of biomarkers of periodontal diseases.

• Keywords: biomarkeri parodontnih bolesti
• Keywords (english): biomarkers of periodontal diseases
• Language: croatian
• URN:NBN: urn:nbn:hr:127:275093
• Study programme: Title: dental medicine; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni/a magistar/magistra dentalne medicine (sveučilišni/a magistar/magistra dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-03-24 12:33:05