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Association of Functional Polymorphism in TPH2 Gene with Alcohol Dependence and Personality Traits: Study in Cloninger’s Type I and Type II Alcohol-Dependent Inpatients
Genes, 14 (2023), 2; 413. https://doi.org/10.3390/genes14020413
Konjevod, Marcela; Rešetar, Mirta; Matošić, Ana; Čičin-Šain, Lipa; Štefulj, Jasminka

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Konjevod, M., Rešetar, M., Matošić, A., Čičin Šain, L. i Štefulj, J. (2023). Association of Functional Polymorphism in TPH2 Gene with Alcohol Dependence and Personality Traits: Study in Cloninger’s Type I and Type II Alcohol-Dependent Inpatients. Genes, 14. (2). doi: 10.3390/genes14020413

Konjevod, Marcela, et al. "Association of Functional Polymorphism in TPH2 Gene with Alcohol Dependence and Personality Traits: Study in Cloninger’s Type I and Type II Alcohol-Dependent Inpatients." Genes, vol. 14, br. 2, 2023. https://doi.org/10.3390/genes14020413

Konjevod, Marcela, Mirta Rešetar, Ana Matošić, Lipa Čičin Šain i Jasminka Štefulj. "Association of Functional Polymorphism in TPH2 Gene with Alcohol Dependence and Personality Traits: Study in Cloninger’s Type I and Type II Alcohol-Dependent Inpatients." Genes 14, br. 2 (2023). https://doi.org/10.3390/genes14020413

Konjevod, M., et al. (2023) 'Association of Functional Polymorphism in TPH2 Gene with Alcohol Dependence and Personality Traits: Study in Cloninger’s Type I and Type II Alcohol-Dependent Inpatients', Genes, 14(2). doi: 10.3390/genes14020413

Konjevod M, Rešetar M, Matošić A, Čičin Šain L, Štefulj J. Association of Functional Polymorphism in TPH2 Gene with Alcohol Dependence and Personality Traits: Study in Cloninger’s Type I and Type II Alcohol-Dependent Inpatients. Genes [Internet]. 04.02.2023. [pristupljeno 15.04.2025.];14(2). doi: 10.3390/genes14020413

M. Konjevod, M. Rešetar, A. Matošić, L. Čičin Šain i J. Štefulj, "Association of Functional Polymorphism in TPH2 Gene with Alcohol Dependence and Personality Traits: Study in Cloninger’s Type I and Type II Alcohol-Dependent Inpatients", Genes, vol. 14, br. 2, Veljača 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:203361. [Citirano: 15.04.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:127:203361
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Naslov (engleski)Association of Functional Polymorphism in TPH2 Gene with Alcohol Dependence and Personality Traits: Study in Cloninger’s Type I and Type II Alcohol-Dependent Inpatients
AutorMarcela Konjevod
AutorMirta Rešetar
AutorAna Matošić
AutorLipa Čičin-Šain
AutorJasminka Štefulj
Autorova ustanovaHrvatsko katoličko sveučilište
Autorova ustanovaInstitut Ruđer Bošković
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Alcohol dependence (AD) is a complex disorder with a poorly understood etiology. In this study, we investigated the relationship between genetic variation in the TPH2 gene, which encodes the enzyme responsible for serotonin synthesis in the brain, and both AD and personality traits, with attention to Cloninger’s types of AD. The study included 373 healthy control subjects, 206 inpatients with type I AD, and 110 inpatients with type II AD. All subjects were genotyped for the functional polymorphism rs4290270 in the TPH2 gene, and AD patients completed the Tridimensional Personality Questionnaire (TPQ). The AA genotype and the A allele of the rs4290270 polymorphism were more frequent in both patient groups compared with the control group. In addition, a negative association was found between the number of A alleles and TPQ scores for harm avoidance in patients with type II, but not type I, AD. These results support the involvement of genetic variations of the serotonergic system in the pathogenesis of AD, especially type II AD. They also suggest that in a subset of patients, genetic variation of TPH2 could potentially influence the development of AD by affecting the personality trait of harm avoidance.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaGenes
Brojčani podacivol. 14, br. 2, 413
e-ISSN2073-4425
DOIhttps://doi.org/10.3390/genes14020413
URN:NBNurn:nbn:hr:127:203361
Datum objave publikacije2023-02-04
URL dokumentahttps://www.mdpi.com/2073-4425/14/2/413
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-10 11:23:21