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The Association between Resistance and Virulence of Klebsiella pneumoniae in High-Risk Clonal Lineages ST86 and ST101
Microorganisms, 12 (2024), 10; 1997. https://doi.org/10.3390/microorganisms12101997
Pristas, Irina; Ujevic, Josip; Bodulić, Kristian; Andrijasevic, Natasa; Bedenic, Branka; Payerl-Pal, Marina; Susic, Edita; Dobrovic, Karolina; De Koster, Sien; Malhotra-Kumar, Surbhi; Tambic Andrasevic, Arjana

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Pristas, I., Ujevic, J., Bodulić, K., Andrijasevic, N., Bedenic, B., Payerl Pal, M. ... Tambic Andrasevic, A. (2024). The Association between Resistance and Virulence of Klebsiella pneumoniae in High-Risk Clonal Lineages ST86 and ST101. Microorganisms, 12. (10). doi: 10.3390/microorganisms12101997

Pristas, Irina, et al. "The Association between Resistance and Virulence of Klebsiella pneumoniae in High-Risk Clonal Lineages ST86 and ST101." Microorganisms, vol. 12, br. 10, 2024. https://doi.org/10.3390/microorganisms12101997

Pristas, Irina, Josip Ujevic, Kristian Bodulić, Natasa Andrijasevic, Branka Bedenic, Marina Payerl Pal, Edita Susic, et al. "The Association between Resistance and Virulence of Klebsiella pneumoniae in High-Risk Clonal Lineages ST86 and ST101." Microorganisms 12, br. 10 (2024). https://doi.org/10.3390/microorganisms12101997

Pristas, I., et al. (2024) 'The Association between Resistance and Virulence of Klebsiella pneumoniae in High-Risk Clonal Lineages ST86 and ST101', Microorganisms, 12(10). doi: 10.3390/microorganisms12101997

Pristas I, Ujevic J, Bodulić K, Andrijasevic N, Bedenic B, Payerl Pal M, i sur.. The Association between Resistance and Virulence of Klebsiella pneumoniae in High-Risk Clonal Lineages ST86 and ST101. Microorganisms [Internet]. 30.09.2024. [pristupljeno 05.03.2025.];12(10). doi: 10.3390/microorganisms12101997

I. Pristas, et al., "The Association between Resistance and Virulence of Klebsiella pneumoniae in High-Risk Clonal Lineages ST86 and ST101", Microorganisms, vol. 12, br. 10, Rujan 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:208907. [Citirano: 05.03.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:127:208907
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Podaci o radu
Naslov (engleski)The Association between Resistance and Virulence of Klebsiella pneumoniae in High-Risk Clonal Lineages ST86 and ST101
AutorIrina Pristas
AutorJosip Ujevic
AutorKristian Bodulić
AutorNatasa Andrijasevic
AutorBranka Bedenic
AutorMarina Payerl-Pal
AutorEdita Susic
AutorKarolina Dobrovic
AutorSien De Koster
AutorSurbhi Malhotra-Kumar
AutorArjana Tambic Andrasevic
Autorova ustanova(Klinička bolnica Dubrava)
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Autorova ustanova(Klinički bolnički centar Zagreb)
Autorova ustanova(Klinika za infektivne bolesti "Dr. Fran Mihaljević")
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Klebsiella pneumoniae is an opportunistic pathogen known for two main pathotypes: classical K. pneumoniae (cKp), often multidrug-resistant and common in hospitals, and hypervirulent K. pneumoniae (hvKp), associated with severe community-acquired infections. The recent emergence of strains combining hypervirulence and resistance is alarming. This study investigates the distribution of sequence types (STs), resistance, and virulence factors in K. pneumoniae strains causing bloodstream and urinary tract infections in Croatia. In 2022, 200 consecutive K. pneumoniae isolates were collected from blood and urine samples across several Croatian hospitals. Whole genome sequencing was performed on 194 isolates. Within the analyzed K. pneumoniae population, the distribution of sequence types was determined with multi-locus sequence typing (MLST) and capsule loci, resistance, and virulence determinants were assessed with the bioinformatics tool Kleborate. The analysis identified 77 different STs, with ST101 (24.6%) being the most prevalent, predominantly linked to the K17 capsular type (CT), invasive device usage, high antimicrobial resistance, and low virulence scores. The highest virulence scores were recorded in ST86 isolates, which were predominantly linked to the K2 CT and included some strains with medium resistance scores. String tests were positive in 19 strains, but only four of those harbored hypermucoviscous genetic determinants. The most prevalent ST101 clone in Croatia demonstrated a diverging association between resistance and virulence. An alarming co-existence of resistance and virulence was recorded in the ST86 strains.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMicroorganisms
Brojčani podacivol. 12, br. 10, 1997
e-ISSN2076-2607
DOIhttps://doi.org/10.3390/microorganisms12101997
URN:NBNurn:nbn:hr:127:208907
Datum objave publikacije2024-09-30
URL dokumentahttps://www.mdpi.com/2076-2607/12/10/1997
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-05 11:27:16