prikaz prve stranice dokumenta Systemic Lipid Metabolism Dysregulation as a Possible Driving Force of Fracture Non-Unions?
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Systemic Lipid Metabolism Dysregulation as a Possible Driving Force of Fracture Non-Unions?
Bioengineering, 11 (2024), 11; 1135. https://doi.org/10.3390/bioengineering11111135
Grgurević, Lovorka; Novak, Ruđer; Jambrošić, Lucija; Močibob, Marko; Jaganjac, Morana; Halasz, Mirna; Salai, Grgur; Hrkač, Stela; Milošević, Milan; Vlahović, Tomislav; Romić, Jeronim; Matičić, Dražen; Vidović, Dinko

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Grgurević, L., Novak, R., Jambrošić, L., Močibob, M., Jaganjac, M., Halasz, M. ... Vidović, D. (2024). Systemic Lipid Metabolism Dysregulation as a Possible Driving Force of Fracture Non-Unions?. Bioengineering, 11. (11). doi: 10.3390/bioengineering11111135

Grgurević, Lovorka, et al. "Systemic Lipid Metabolism Dysregulation as a Possible Driving Force of Fracture Non-Unions?." Bioengineering, vol. 11, br. 11, 2024. https://doi.org/10.3390/bioengineering11111135

Grgurević, Lovorka, Ruđer Novak, Lucija Jambrošić, Marko Močibob, Morana Jaganjac, Mirna Halasz, Grgur Salai, et al. "Systemic Lipid Metabolism Dysregulation as a Possible Driving Force of Fracture Non-Unions?." Bioengineering 11, br. 11 (2024). https://doi.org/10.3390/bioengineering11111135

Grgurević, L., et al. (2024) 'Systemic Lipid Metabolism Dysregulation as a Possible Driving Force of Fracture Non-Unions?', Bioengineering, 11(11). doi: 10.3390/bioengineering11111135

Grgurević L, Novak R, Jambrošić L, Močibob M, Jaganjac M, Halasz M, i sur.. Systemic Lipid Metabolism Dysregulation as a Possible Driving Force of Fracture Non-Unions?. Bioengineering [Internet]. 11.11.2024. [pristupljeno 20.12.2024.];11(11). doi: 10.3390/bioengineering11111135

L. Grgurević, et al., "Systemic Lipid Metabolism Dysregulation as a Possible Driving Force of Fracture Non-Unions?", Bioengineering, vol. 11, br. 11, Studeni 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:152291. [Citirano: 20.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:127:152291
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Naslov (engleski)Systemic Lipid Metabolism Dysregulation as a Possible Driving Force of Fracture Non-Unions?
AutorLovorka Grgurević
AutorRuđer Novak
AutorLucija Jambrošić
AutorMarko Močibob
AutorMorana Jaganjac
AutorMirna Halasz
AutorGrgur Salai
AutorStela Hrkač
AutorMilan Milošević
AutorTomislav Vlahović
AutorJeronim Romić
AutorDražen Matičić
AutorDinko Vidović
Autorova ustanovaInstitut Ruđer Bošković
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Introduction: Non-unions are fractures that do not heal properly, resulting in a false joint formation at the fracture site. This condition leads to major health issues and imposes a burden on national healthcare systems. The etiology of non-unions is still not fully understood; therefore, we aimed to identify potential systemic factors that may contribute to their formation. Materials and methods: We conducted a cross-sectional concomitant proteomic and metabolomic pilot study of blood plasma in patients with non-unions (N = 11) and compared them with patients with bone fracture in the normal active healing phase (N = 12). Results: We found five significantly upregulated proteins in the non-union group: immunoglobulin heavy variable 3–74, immunoglobulin lambda variable 2–18, low-density lipoprotein receptor-related protein 4, zinc-alpha-2-glycoprotein, and serum amyloid A-1 protein; and we found one downregulated protein: cystatin-C. The metabolomic study found differences in alanine, aspartate and glutamate metabolism pathways between two groups. Conclusions: The combined results of proteomic and metabolomic analyses suggest that the dysregulation of lipid metabolism may contribute to non-union formation.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBioengineering
Brojčani podacivol. 11, br. 11, 1135
e-ISSN2306-5354
DOIhttps://doi.org/10.3390/bioengineering11111135
URN:NBNurn:nbn:hr:127:152291
Datum objave publikacije2024-11-11
URL dokumentahttps://www.mdpi.com/2306-5354/11/11/1135
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-12-20 11:54:12