prikaz prve stranice dokumenta Comparison of the Skin Microbiota in the Periocular Region between Patients with Inflammatory Skin Diseases and Healthy Participants: A Preliminary Study
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Comparison of the Skin Microbiota in the Periocular Region between Patients with Inflammatory Skin Diseases and Healthy Participants: A Preliminary Study
Life, 14 (2024), 9; 1091. https://doi.org/10.3390/life14091091
Ferček, Iva; Ozretić, Petar; Tambić-Andrašević, Arjana; Trajanoski, Slave; Ćesić, Diana; Jelić, Marko; Geber, Goran; Žaja, Orjena; Paić, Josipa; Lugović-Mihić, Liborija; Čivljak, Rok

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Ferček, I., Ozretić, P., Tambić Andrašević, A., Trajanoski, S., Ćesić, D., Jelić, M. ... Čivljak, R. (2024). Comparison of the Skin Microbiota in the Periocular Region between Patients with Inflammatory Skin Diseases and Healthy Participants: A Preliminary Study. Life, 14. (9). doi: 10.3390/life14091091

Ferček, Iva, et al. "Comparison of the Skin Microbiota in the Periocular Region between Patients with Inflammatory Skin Diseases and Healthy Participants: A Preliminary Study." Life, vol. 14, br. 9, 2024. https://doi.org/10.3390/life14091091

Ferček, Iva, Petar Ozretić, Arjana Tambić Andrašević, Slave Trajanoski, Diana Ćesić, Marko Jelić, Goran Geber, et al. "Comparison of the Skin Microbiota in the Periocular Region between Patients with Inflammatory Skin Diseases and Healthy Participants: A Preliminary Study." Life 14, br. 9 (2024). https://doi.org/10.3390/life14091091

Ferček, I., et al. (2024) 'Comparison of the Skin Microbiota in the Periocular Region between Patients with Inflammatory Skin Diseases and Healthy Participants: A Preliminary Study', Life, 14(9). doi: 10.3390/life14091091

Ferček I, Ozretić P, Tambić Andrašević A, Trajanoski S, Ćesić D, Jelić M, i sur.. Comparison of the Skin Microbiota in the Periocular Region between Patients with Inflammatory Skin Diseases and Healthy Participants: A Preliminary Study. Life [Internet]. 30.08.2024. [pristupljeno 08.12.2024.];14(9). doi: 10.3390/life14091091

I. Ferček, et al., "Comparison of the Skin Microbiota in the Periocular Region between Patients with Inflammatory Skin Diseases and Healthy Participants: A Preliminary Study", Life, vol. 14, br. 9, Kolovoz 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:402910. [Citirano: 08.12.2024.]

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Naslov (engleski)Comparison of the Skin Microbiota in the Periocular Region between Patients with Inflammatory Skin Diseases and Healthy Participants: A Preliminary Study
AutorIva Ferček
AutorPetar Ozretić
AutorArjana Tambić-Andrašević
AutorSlave Trajanoski
AutorDiana Ćesić
AutorMarko Jelić
AutorGoran Geber
AutorOrjena Žaja
AutorJosipa Paić
AutorLiborija Lugović-Mihić
MBZ: 215056
AutorRok Čivljak
Autorova ustanovaInstitut Ruđer Bošković
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Autorova ustanova(Klinika za infektivne bolesti "Dr. Fran Mihaljević")
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
(1) Background: Periocular or periorbital dermatitis is a common term for all inflammatory skin diseases affecting the area of skin around the eyes. The clear etiopathogenesis of periocular dermatitis is still not fully understood. Advances in molecular techniques for studying microorganisms living in and on our bodies have highlighted the microbiome as a possible contributor to disease, as well as a promising diagnostic marker and target for innovative treatments. The aim of this study was to compare the composition and diversity of the skin microbiota in the periocular region between healthy individuals and individuals affected by the specific entity of periocular dermatitis. (2) Methods: A total of 35 patients with periocular dermatitis and 39 healthy controls were enrolled in the study. After a skin swab from the periocular region was taken from all participants, DNA extraction and 16S rRNA gene amplicon sequencing using Illumina NovaSeq technology were performed. (3) Results: Staphylococcus and Corynebacterium were the most abundant bacterial genera in the microbiota of healthy skin. Analysis of alpha diversity revealed a statistically significant change (p < 0.05) in biodiversity based on the Faith’s PD index between patients and healthy individuals. We did not observe changes in beta diversity. The linear discriminant analysis effect size (LEfSe) revealed that Rothia, Corynebacterium, Bartonella, and Paracoccus were enriched in patients, and Anaerococcus, Bacteroides, Porphyromonas, and Enhydrobacter were enriched in healthy controls. (4) Conclusions: According to the results obtained, we assume that the observed changes in the bacterial microbiota on the skin, particularly Gram-positive anaerobic cocci and skin commensals of the genus Corynebacterium, could be one of the factors in the pathogenesis of the investigated inflammatory diseases. The identified differences in the microbiota between healthy individuals and patients with periocular dermatitis should be further investigated.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaLife
Brojčani podacivol. 14, br. 9, 1091
e-ISSN2075-1729
DOIhttps://doi.org/10.3390/life14091091
URN:NBNurn:nbn:hr:127:402910
Datum objave publikacije2024-08-30
URL dokumentahttps://www.mdpi.com/2075-1729/14/9/1091
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-11-11 12:27:33