prikaz prve stranice dokumenta Beta-HPV types in patients with head and neck pathology and in healthy subjects
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Beta-HPV types in patients with head and neck pathology and in healthy subjects
Journal of Clinical Virology, 82 (2016); 159-165. https://doi.org/10.1016/j.jcv.2016.07.019
Sabol, Ivan; Smahelova, Jana; Klozar, Jan; Mravak-Stipetic, Marinka; Gheit, Tarik; Tommasino, Massimo; Grce, Magdalena; Tachezy, Ruth

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Sabol, I., Smahelova, J., Klozar, J., Mravak Stipetic, M., Gheit, T., Tommasino, M. ... Tachezy, R. (2016). Beta-HPV types in patients with head and neck pathology and in healthy subjects. Journal of Clinical Virology, 82., 159-165. doi: 10.1016/j.jcv.2016.07.019

Sabol, Ivan, et al. "Beta-HPV types in patients with head and neck pathology and in healthy subjects." Journal of Clinical Virology, vol. 82, 2016, str. 159-165. https://doi.org/10.1016/j.jcv.2016.07.019

Sabol, Ivan, Jana Smahelova, Jan Klozar, Marinka Mravak Stipetic, Tarik Gheit, Massimo Tommasino, Magdalena Grce i Ruth Tachezy. "Beta-HPV types in patients with head and neck pathology and in healthy subjects." Journal of Clinical Virology 82 (2016): 159-165. https://doi.org/10.1016/j.jcv.2016.07.019

Sabol, I., et al. (2016) 'Beta-HPV types in patients with head and neck pathology and in healthy subjects', Journal of Clinical Virology, 82, str. 159-165. doi: 10.1016/j.jcv.2016.07.019

Sabol I, Smahelova J, Klozar J, Mravak Stipetic M, Gheit T, Tommasino M, i sur.. Beta-HPV types in patients with head and neck pathology and in healthy subjects. Journal of Clinical Virology [Internet]. 09.2016. [pristupljeno 14.11.2024.];82:159-165. doi: 10.1016/j.jcv.2016.07.019

I. Sabol, et al., "Beta-HPV types in patients with head and neck pathology and in healthy subjects", Journal of Clinical Virology, vol. 82, str. 159-165, Rujan 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:624482. [Citirano: 14.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:127:624482
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Podaci o radu
Naslov (engleski)Beta-HPV types in patients with head and neck pathology and in healthy subjects
AutorIvan Sabol
AutorJana Smahelova
AutorJan Klozar
AutorMarinka Mravak-Stipetic
AutorTarik Gheit
AutorMassimo Tommasino
AutorMagdalena Grce
AutorRuth Tachezy
Autorova ustanovaInstitut Ruđer Bošković
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Dentalna medicina
Sažetak (engleski)
Background Human papillomaviruses (HPV) are a heterogeneous group of viruses classified into five genera. The beta-HPV type (beta-PV) infection is very common but mostly asymptomatic in immunocompetent individuals. However, beta-PVs play a role in Epidermodysplasia verruciformis and possibly in non-melanoma skin cancer. Head and neck cancer (HNC) is a common cancer type worldwide and high-risk alpha-PV involvement in HNC has been extensively studied but beta-PV types have rarely been the focus of such studies. Objectives To evaluate the prevalence of beta-PV types in HNC, subjects with non-malignant or potentially pre-malignant oral lesions, and healthy controls. Study design The frequency of different beta-PVs in samples from oral (n = 35) and oropharyngeal (n = 35) cancer patients, gender- and age-matched healthy controls (n = 70), and subjects with various non-malignant or potentially pre-malignant oral lesions (n = 102) was assessed by a highly sensitive, bead-based, multiplex genotyping assay. Results Overall, 54.8% of all tested samples contained at least one beta-PV type. Even though the correlation between types found in lavage and tissue specimens from cancer patients was low, there was a large statistically significant difference between oropharyngeal cancer patients and matched controls for HPV5 (P = 0.003; OR = 15.58) and between both oral (P = 0.026; OR = 5.7) and oropharyngeal cancer patients (P = 0.002; OR = 25.5) and controls for HPV122. In addition, there was no correlation between the prevalence of alpha and beta-PVs in the study patients. Conclusion The study provides new data on the prevalence of beta-PVs in HNC. HPV5 was found significantly associated with HNC as already observed by other studies. Additionally, the significant association of HPV122 with HNC might warrant further study as this type has not been extensively studied so far.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Clinical Virology
Brojčani podacivol. 82, str. 159-165
p-ISSN1386-6532
DOIhttps://doi.org/10.1016/j.jcv.2016.07.019
URN:NBNurn:nbn:hr:127:624482
Datum objave publikacije2016-09
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S1386653216301901
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-10-30 09:21:45