prikaz prve stranice dokumenta Significance of stroma in biology of oral squamous cell carcinoma
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Significance of stroma in biology of oral squamous cell carcinoma
Tumori Journal, 104 (2018), 1; 9-14. https://doi.org/10.5301/tj.5000673
Vucicevic Boras, Vanja; Fucic, Aleksandra; Virag, Mihajlo; Gabric, Dragana; Blivajs, Igor; Tomasovic-Loncaric, Cedna; Rakusic, Zoran; Bisof, Vesna; Novere, Nicolas Le; Velimir Vrdoljak, Danko

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Vucicevic Boras, V., Fucic, A., Virag, M., Gabric, D., Blivajs, I., Tomasovic Loncaric, C. ... Velimir Vrdoljak, D. (2018). Significance of stroma in biology of oral squamous cell carcinoma. Tumori Journal, 104. (1), 9-14. doi: 10.5301/tj.5000673

Vucicevic Boras, Vanja, et al. "Significance of stroma in biology of oral squamous cell carcinoma." Tumori Journal, vol. 104, br. 1, 2018, str. 9-14. https://doi.org/10.5301/tj.5000673

Vucicevic Boras, Vanja, Aleksandra Fucic, Mihajlo Virag, Dragana Gabric, Igor Blivajs, Cedna Tomasovic Loncaric, Zoran Rakusic, Vesna Bisof, Nicolas Le Novere i Danko Velimir Vrdoljak. "Significance of stroma in biology of oral squamous cell carcinoma." Tumori Journal 104, br. 1 (2018): 9-14. https://doi.org/10.5301/tj.5000673

Vucicevic Boras, V., et al. (2018) 'Significance of stroma in biology of oral squamous cell carcinoma', Tumori Journal, 104(1), str. 9-14. doi: 10.5301/tj.5000673

Vucicevic Boras V, Fucic A, Virag M, Gabric D, Blivajs I, Tomasovic Loncaric C, i sur.. Significance of stroma in biology of oral squamous cell carcinoma. Tumori Journal [Internet]. 27.04.2018. [pristupljeno 18.11.2024.];104(1):9-14. doi: 10.5301/tj.5000673

V. Vucicevic Boras, et al., "Significance of stroma in biology of oral squamous cell carcinoma", Tumori Journal, vol. 104, br. 1, str. 9-14, Travanj 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:839723. [Citirano: 18.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:127:839723
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Podaci o radu
Naslov (engleski)Significance of stroma in biology of oral squamous cell carcinoma
AutorVanja Vucicevic Boras
AutorAleksandra Fucic
AutorMihajlo Virag
AutorDragana Gabric
AutorIgor Blivajs
AutorCedna Tomasovic-Loncaric
AutorZoran Rakusic
AutorVesna Bisof
AutorNicolas Le Novere
AutorDanko Velimir Vrdoljak
Autorova ustanova(Klinička bolnica Dubrava)
Autorova ustanova(Klinički bolnički centar Zagreb)
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Dentalna medicina
Sažetak (engleski)
The worldwide annual incidence of oral squamous cell carcinoma (OSCC) is over 300,000 cases with a mortality rate of 48%. This cancer type accounts for 90% of all oral cancers, with the highest incidence in men over 50 years of age. A significantly increased risk of developing OSCC exists among smokers and people who consume alcohol daily. OSCC is an aggressive cancer that metastasizes rapidly. Despite the development of new therapies in the treatment of OSCC, no significant increase in 5-year survival has been recorded in the past decades. The latest research suggests focus should be put on examining tumor stroma activation within OSCC, as the stroma may contain cells that can produce signal molecules and a microenvironment crucial for the development of metastases. The aim of this review is to provide an insight into the factors that activate OSCC stroma and hence faciliate neoplastic progression. It is based on the currently available data on the role and interaction between metalloproteinases, cytokines, growth factors, hypoxia factor and extracellular adhesion proteins in the stroma of OSCC and neoplastic cells. Their interplay is additionally presented using the Systems Biology Graphical Notation in order to sublimate the collected knowledge and enable the more efficient recognition of possible new biomarkers in the diagnostics and follow-up of OSCC or in finding new therapeutic targets.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaTumori Journal
Brojčani podacivol. 104, br. 1, str. 9-14
p-ISSN0300-8916
e-ISSN2038-2529
DOIhttps://doi.org/10.5301/tj.5000673
URN:NBNurn:nbn:hr:127:839723
Datum objave publikacije2018-04-27
URL dokumentahttps://journals.sagepub.com/doi/10.5301/tj.5000673
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-10-25 09:41:57