Influence of saliva on the results of global laboratory coagulation tests

Znanstveni rad - Izvorni znanstveni rad

• Autor: B Špiljak
• Autor: L Šimunović
• Autor: I Lapić
• Autor: D Rogić
• Autor: S Špalj
• Autor: L Vuletić
• Autorova ustanova: Sveučilište u Rijeci
• Autorova ustanova: (Klinički bolnički centar Rijeka)
• Autorova ustanova: (Klinički bolnički centar Zagreb)
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet
• Autorova ustanova: Sveučilište u Zagrebu; Stomatološki fakultet
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Dentalna medicina

Sažetak (engleski)

Background: Oral wounds inevitably come into contact with saliva which can affect the time needed for bleeding to stop. The influence of saliva can be non-specific, related to dilution of blood, and/or mediated by salivary factors that affect haemostasis directly. The aim of this study was to assess if mixing blood with an individual's saliva would affect the rate of its coagulation measured by global coagulation tests, prothrombin time (PT) and activated partial thromboplastin time (APTT). Methods: The study included 30 healthy non-smoking volunteers. Paired blood and unstimulated saliva samples were obtained from each participant and PT and APTT were determined in blood, blood + saliva and blood + water mixtures. Coagulation tests were performed using the mechanical clot detection method. Results: PT was significantly longer in both blood + saliva and blood + water mixtures compared to blood alone. APTT was significantly longer only in blood + water mixture compared to blood. Conclusions: Similarly prolonged PT in both mixtures suggests that both saliva and water prolong coagulation evenly due to their non-specific effect of blood dilution. The finding that APTT was significantly prolonged only when blood was mixed with water could indicate presence of tissue factor in saliva, however, in a concentration too low to influence the results of PT.

• Ključne riječi (engleski): Activated partial thromboplastin time; blood coagulation; blood coagulation tests; prothrombin time; unstimulated saliva
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - međunarodna recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Australian Dental Journal
• Brojčani podaci: vol. 65, br. 3, str. 205-209
• p-ISSN: 0045-0421
• e-ISSN: 1834-7819
• DOI: https://doi.org/10.1111/adj.12753
• URN:NBN: urn:nbn:hr:127:172185
• Datum objave publikacije: 2020-03-27
• URL dokumenta: https://onlinelibrary.wiley.com/doi/10.1111/adj.12753
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-10-22 10:05:58