prikaz prve stranice dokumenta Opiorphin as a biomarker of orofacial conditions: a meta-analysis
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Opiorphin as a biomarker of orofacial conditions: a meta-analysis
Scientific Reports, 13 (2023), 1; 15533. https://doi.org/10.1038/s41598-023-42051-y
Porporatti, André Luís; de Oliveira Machado, Claudia Aparecida; Alajbeg, Ivan; Alajbeg, Iva Z.; Paszynska, Elzbieta; Dmitrzak-Weglarz, Monika; Braud, Adeline; Boucher, Yves

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Porporatti, A. L., de Oliveira Machado, C. A., Alajbeg, I., Alajbeg, I. Z., Paszynska, E., Dmitrzak Weglarz, M. ... Boucher, Y. (2023). Opiorphin as a biomarker of orofacial conditions: a meta-analysis. Scientific Reports, 13. (1). doi: 10.1038/s41598-023-42051-y

Porporatti, André Luís, et al. "Opiorphin as a biomarker of orofacial conditions: a meta-analysis." Scientific Reports, vol. 13, br. 1, 2023. https://doi.org/10.1038/s41598-023-42051-y

Porporatti, André Luís, Claudia Aparecida de Oliveira Machado, Ivan Alajbeg, Iva Z. Alajbeg, Elzbieta Paszynska, Monika Dmitrzak Weglarz, Adeline Braud i Yves Boucher. "Opiorphin as a biomarker of orofacial conditions: a meta-analysis." Scientific Reports 13, br. 1 (2023). https://doi.org/10.1038/s41598-023-42051-y

Porporatti, A. L., et al. (2023) 'Opiorphin as a biomarker of orofacial conditions: a meta-analysis', Scientific Reports, 13(1). doi: 10.1038/s41598-023-42051-y

Porporatti AL, de Oliveira Machado CA, Alajbeg I, Alajbeg IZ, Paszynska E, Dmitrzak Weglarz M, i sur.. Opiorphin as a biomarker of orofacial conditions: a meta-analysis. Scientific Reports [Internet]. 19.09.2023. [pristupljeno 03.07.2024.];13(1). doi: 10.1038/s41598-023-42051-y

A. L. Porporatti, et al., "Opiorphin as a biomarker of orofacial conditions: a meta-analysis", Scientific Reports, vol. 13, br. 1, Rujan 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:841906. [Citirano: 03.07.2024.]

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Naslov (engleski)Opiorphin as a biomarker of orofacial conditions: a meta-analysis
AutorAndré Luís Porporatti
AutorClaudia Aparecida de Oliveira Machado
AutorIvan Alajbeg
AutorIva Z. Alajbeg
AutorElzbieta Paszynska
AutorMonika Dmitrzak-Weglarz
AutorAdeline Braud
AutorYves Boucher
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Dentalna medicina
Sažetak (engleski)
Abstract The aim of this meta-analysis was to answer the following question: “Are there any differences in opiorphin biomarker concentrations between different orofacial conditions and controls?”. Two reviewers searched for observational studies that evaluated the levels of opiorphin in orofacial conditions, annotated in seven main databases and three that compile gray literature. Of the 443 articles obtained initially, 8 met the inclusion criteria for quantitative analyses. Relative percentages showed a mean 24.1% higher opiorphin concentration in chronic conditions (Burning Mouth Syndrome, Oral Potentially Malignant Diseases and Temporomandibular Disorder) compared to controls; 33.2% higher opiorphin in sustained pain (Symptomatic Irreversible Pulpitis, Symptomatic Apical Periodontitis, Painful Oral Soft-tissue conditions); and 21.7% higher opiorphin after stimuli (Corneal Foreign Body, Capsaicin). Meta-analysis revealed a standardized mean difference of 0.62 [0.02, 1.22] in the absolute concentration of opiorphin in saliva for the chronic group compared to the control. The analogous values for the sustained group and the stimulated group were 2.24 [0.34, 4.14] and 0.43 [0.00, 0.85], respectively. No differences in opiorphin levels were found for ‘after Local Anesthesia before Tooth Extraction’ or for apicoectomy. Based on the available evidence, in general, a statistically higher level of opiorphin is found in orofacial conditions. Salivary opiorphin levels are elevated in chronic, persisted and acute pain conditions, presumably reflecting a physiological homeostatic adaptative response to different conditions such as stress or pain. Salivary opiorphin might therefore be used as a valuable biomarker in several oral disorders.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScientific Reports
Brojčani podacivol. 13, br. 1, 15533
e-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-023-42051-y
URN:NBNurn:nbn:hr:127:841906
Datum objave publikacije2023-09-19
URL dokumentahttps://www.nature.com/articles/s41598-023-42051-y
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-07-03 10:31:27