prikaz prve stranice dokumenta Association of BRAF V600E Mutant Allele Proportion with the Dissemination Stage of Papillary Thyroid Cancer
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Association of BRAF V600E Mutant Allele Proportion with the Dissemination Stage of Papillary Thyroid Cancer
Biomedicines, 12 (2024), 3; 477. https://doi.org/10.3390/biomedicines12030477
Blažeković, Ivan; Šamija, Ivan; Periša, Josipa; Gall Trošelj, Koraljka; Regović Džombeta, Tihana; Radulović, Petra; Romić, Matija; Granić, Roko; Šiško Markoš, Ines; Fröbe, Ana; Kusić, Zvonko; Jukić, Tomislav

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Blažeković, I., Šamija, I., Periša, J., Gall Trošelj, K., Regović Džombeta, T., Radulović, P. ... Jukić, T. (2024). Association of BRAF V600E Mutant Allele Proportion with the Dissemination Stage of Papillary Thyroid Cancer. Biomedicines, 12. (3). doi: 10.3390/biomedicines12030477

Blažeković, Ivan, et al. "Association of BRAF V600E Mutant Allele Proportion with the Dissemination Stage of Papillary Thyroid Cancer." Biomedicines, vol. 12, br. 3, 2024. https://doi.org/10.3390/biomedicines12030477

Blažeković, Ivan, Ivan Šamija, Josipa Periša, Koraljka Gall Trošelj, Tihana Regović Džombeta, Petra Radulović, Matija Romić, et al. "Association of BRAF V600E Mutant Allele Proportion with the Dissemination Stage of Papillary Thyroid Cancer." Biomedicines 12, br. 3 (2024). https://doi.org/10.3390/biomedicines12030477

Blažeković, I., et al. (2024) 'Association of BRAF V600E Mutant Allele Proportion with the Dissemination Stage of Papillary Thyroid Cancer', Biomedicines, 12(3). doi: 10.3390/biomedicines12030477

Blažeković I, Šamija I, Periša J, Gall Trošelj K, Regović Džombeta T, Radulović P, i sur.. Association of BRAF V600E Mutant Allele Proportion with the Dissemination Stage of Papillary Thyroid Cancer. Biomedicines [Internet]. 21.02.2024. [pristupljeno 05.12.2024.];12(3). doi: 10.3390/biomedicines12030477

I. Blažeković, et al., "Association of BRAF V600E Mutant Allele Proportion with the Dissemination Stage of Papillary Thyroid Cancer", Biomedicines, vol. 12, br. 3, Veljača 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:464372. [Citirano: 05.12.2024.]

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Naslov (engleski)Association of BRAF V600E Mutant Allele Proportion with the Dissemination Stage of Papillary Thyroid Cancer
AutorIvan Blažeković
AutorIvan Šamija
AutorJosipa Periša
AutorKoraljka Gall Trošelj
AutorTihana Regović Džombeta
AutorPetra Radulović
AutorMatija Romić
AutorRoko Granić
AutorInes Šiško Markoš
AutorAna Fröbe
AutorZvonko Kusić
AutorTomislav Jukić
Autorova ustanovaInstitut Ruđer Bošković
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
The early identification of aggressive forms of cancer is of high importance in treating papillary thyroid cancer (PTC). Disease dissemination is a major factor influencing patient survival. Mutation status of BRAF oncogene, BRAF V600E, is proposed to be an indicator of disease recurrence; however, its influence on PTC dissemination has not been deciphered. This study aimed to explore the association of the frequency of BRAF V600E alleles in PTC with disease dissemination. In this study, 173 PTC samples were analyzed, measuring the proportion of BRAF V600E alleles by qPCR, which was then normalized against the proportion of tumor cells. Semiquantitative analysis of BRAF V600E mutant protein was performed by immunohistochemistry. The BRAF V600E mutation was present in 60% of samples, while the normalized frequency of mutated BRAF alleles ranged from 1.55% to 92.06%. There was no significant association between the presence and/or proportion of the BRAF V600E mutation with the degree of PTC dissemination. However, the presence of the BRAF mutation was significantly linked with angioinvasion. This study’s results suggest that there is a heterogeneous distribution of the BRAF mutation and the presence of oligoclonal forms of PTC. It is likely that the BRAF mutation alone does not significantly contribute to PTC aggressiveness.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 12, br. 3, 477
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines12030477
URN:NBNurn:nbn:hr:127:464372
Datum objave publikacije2024-02-21
URL dokumentahttps://www.mdpi.com/2227-9059/12/3/477
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-04-09 09:08:22