prikaz prve stranice dokumenta Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions
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Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions
International Journal of Molecular Sciences, 25 (2023), 1; 236. https://doi.org/10.3390/ijms25010236
Pondeljak, Nives; Lugović-Mihić, Liborija; Tomić, Lucija; Parać, Ena; Pedić, Lovre; Lazić-Mosler, Elvira

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Pondeljak, N., Lugović Mihić, L., Tomić, L., Parać, E., Pedić, L. i Lazić Mosler, E. (2023). Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions. International Journal of Molecular Sciences, 25. (1). doi: 10.3390/ijms25010236

Pondeljak, Nives, et al. "Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions." International Journal of Molecular Sciences, vol. 25, br. 1, 2023. https://doi.org/10.3390/ijms25010236

Pondeljak, Nives, Liborija Lugović Mihić, Lucija Tomić, Ena Parać, Lovre Pedić i Elvira Lazić Mosler. "Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions." International Journal of Molecular Sciences 25, br. 1 (2023). https://doi.org/10.3390/ijms25010236

Pondeljak, N., et al. (2023) 'Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions', International Journal of Molecular Sciences, 25(1). doi: 10.3390/ijms25010236

Pondeljak N, Lugović Mihić L, Tomić L, Parać E, Pedić L, Lazić Mosler E. Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions. International Journal of Molecular Sciences [Internet]. 23.12.2023. [pristupljeno 04.12.2024.];25(1). doi: 10.3390/ijms25010236

N. Pondeljak, L. Lugović Mihić, L. Tomić, E. Parać, L. Pedić i E. Lazić Mosler, "Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions", International Journal of Molecular Sciences, vol. 25, br. 1, Prosinac 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:500792. [Citirano: 04.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:127:500792
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Podaci o radu
Naslov (engleski)Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions
AutorNives Pondeljak
AutorLiborija Lugović-Mihić
MBZ: 215056
AutorLucija Tomić
AutorEna Parać
AutorLovre Pedić
AutorElvira Lazić-Mosler
Autorova ustanovaHrvatsko katoličko sveučilište
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
(Katedra za dermatovenerologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Dermatovenerologija
Sažetak (engleski)
The epidermis serves many vital roles, including protecting the body from external influences and healing eventual injuries. It is maintained by an incredibly complex and perfectly coordinated keratinization process. In this process, desquamation is essential for the differentiation of epidermal basal progenitor cells into enucleated corneocytes, which subsequently desquamate through programmed death. Numerous factors control keratinocyte differentiation: epidermal growth factor, transforming growth factor-α, keratinocyte growth factor, interleukins IL-1-β and IL-6, elevated vitamin A levels, and changes in Ca2+ concentration. The backbone of the keratinocyte transformation process from mitotically active basal cells into fully differentiated, enucleated corneocytes is the expression of specific proteins and the creation of a Ca2+ and pH gradient at precise locations within the epidermis. Skin keratinization disorders (histologically characterized predominantly by dyskeratosis, parakeratosis, and hyperkeratosis) may be categorized into three groups: defects in the α-helical rod pattern, defects outside the α-helical rod domain, and disorders of keratin-associated proteins. Understanding the process of keratinization is essential for the pathogenesis of many dermatological diseases because improper desquamation and epidermopoiesis/keratinization (due to genetic mutations of factors or due to immune pathological processes) can lead to various conditions (ichthyoses, palmoplantar keratodermas, psoriasis, pityriasis rubra pilaris, epidermolytic hyperkeratosis, and others).
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 25, br. 1, 236
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms25010236
URN:NBNurn:nbn:hr:127:500792
Datum objave publikacije2023-12-23
URL dokumentahttps://www.mdpi.com/1422-0067/25/1/236
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2024-02-15 07:51:18