prikaz prve stranice dokumenta Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry
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Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry
Cells, 12 (2023), 14; 12141841. https://doi.org/10.3390/cells12141841
Krasic, Jure; Skara Abramovic, Lucija; Himelreich Peric, Marta; Vanjorek, Vedran; Gangur, Marko; Zovko, Dragana; Malnar, Marina; Masic, Silvija; Demirovic, Alma; Juric, Bernardica; Ulamec, Monika; Coric, Marijana; Jezek, Davor; Kulis, Tomislav; Sincic, Nino Više autora...

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Krasic, J., Skara Abramovic, L., Himelreich Peric, M., Vanjorek, V., Gangur, M., Zovko, D. ... Sincic, N. (2023). Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry. Cells, 12. (14). doi: 10.3390/cells12141841

Krasic, Jure, et al. "Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry." Cells, vol. 12, br. 14, 2023. https://doi.org/10.3390/cells12141841

Krasic, Jure, Lucija Skara Abramovic, Marta Himelreich Peric, Vedran Vanjorek, Marko Gangur, Dragana Zovko, Marina Malnar, et al. "Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry." Cells 12, br. 14 (2023). https://doi.org/10.3390/cells12141841

Krasic, J., et al. (2023) 'Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry', Cells, 12(14). doi: 10.3390/cells12141841

Krasic J, Skara Abramovic L, Himelreich Peric M, Vanjorek V, Gangur M, Zovko D, i sur.. Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry. Cells [Internet]. 13.07.2023. [pristupljeno 19.04.2024.];12(14). doi: 10.3390/cells12141841

J. Krasic, et al., "Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry", Cells, vol. 12, br. 14, Srpanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:136123. [Citirano: 19.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:127:136123
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Naslov (engleski)Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry
AutorJure Krasic
AutorLucija Skara Abramovic
AutorMarta Himelreich Peric
AutorVedran Vanjorek
AutorMarko Gangur
AutorDragana Zovko
AutorMarina Malnar
AutorSilvija Masic
AutorAlma Demirovic
AutorBernardica Juric
AutorMonika Ulamec
AutorMarijana Coric
AutorDavor Jezek
AutorTomislav Kulis
AutorNino Sincic
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Autorova ustanova(Klinički bolnički centar Zagreb)
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
The accurate management of testicular germ cell tumors (TGCTs) depends on identifying the individual histological tumor components. Currently available data on protein expression in TGCTs are limited. The human protein atlas (HPA) is a comprehensive resource presenting the expression and localization of proteins across tissue types and diseases. In this study, we have compared the data from the HPA with our in-house immunohistochemistry on core TGCT diagnostic genes to test reliability and potential biomarker genes. We have compared the protein expression of 15 genes in TGCT patients and non-neoplastic testicles with the data from the HPA. Protein expression was converted into diagnostic positivity. Our study discovered discrepancies in three of the six core TGCT diagnostic genes, POU5F1, KIT and SOX17 in HPA. DPPA3, CALCA and TDGF1 were presented as potential novel TGCT biomarkers. MGMT was confirmed while RASSF1 and PRSS21 were identified as biomarkers of healthy testicular tissue. Finally, SALL4, SOX17, RASSF1 and PRSS21 dysregulation in the surrounding testicular tissue with complete preserved spermatogenesis of TGCT patients was detected, a potential early sign of neoplastic transformation. We highlight the importance of a multidisciplinary collaborative approach to fully understand the protein landscape of human testis and its pathologies.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCells
Brojčani podacivol. 12, br. 14, 12141841
e-ISSN2073-4409
DOIhttps://doi.org/10.3390/cells12141841
URN:NBNurn:nbn:hr:127:136123
Datum objave publikacije2023-07-13
URL dokumentahttps://www.mdpi.com/2073-4409/12/14/1841
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-08-21 08:11:45