prikaz prve stranice dokumenta Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria
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Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria
Life, 13 (2023), 6; 1280. https://doi.org/10.3390/life13061280
Ćesić, Diana; Lugović Mihić, Liborija; Ozretić, Petar; Lojkić, Ivana; Buljan, Marija; Šitum, Mirna; Zovak, Mario; Vidović, Dinko; Mijić, August; Galić, Nada; Tambić Andrašević, Arjana

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Ćesić, D., Lugović Mihić, L., Ozretić, P., Lojkić, I., Buljan, M., Šitum, M. ... Tambić Andrašević, A. (2023). Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria. Life, 13. (6). doi: 10.3390/life13061280

Ćesić, Diana, et al. "Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria." Life, vol. 13, br. 6, 2023. https://doi.org/10.3390/life13061280

Ćesić, Diana, Liborija Lugović Mihić, Petar Ozretić, Ivana Lojkić, Marija Buljan, Mirna Šitum, Mario Zovak, et al. "Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria." Life 13, br. 6 (2023). https://doi.org/10.3390/life13061280

Ćesić, D., et al. (2023) 'Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria', Life, 13(6). doi: 10.3390/life13061280

Ćesić D, Lugović Mihić L, Ozretić P, Lojkić I, Buljan M, Šitum M, i sur.. Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria. Life [Internet]. 30.05.2023. [pristupljeno 23.04.2024.];13(6). doi: 10.3390/life13061280

D. Ćesić, et al., "Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria", Life, vol. 13, br. 6, Svibanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:290626. [Citirano: 23.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:127:290626
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Podaci o radu
Naslov (engleski)Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria
AutorDiana Ćesić
AutorLiborija Lugović Mihić
MBZ: 215056
AutorPetar Ozretić
AutorIvana Lojkić
AutorMarija Buljan
AutorMirna Šitum
AutorMario Zovak
AutorDinko Vidović
AutorAugust Mijić
AutorNada Galić
MBZ: 192110
AutorArjana Tambić Andrašević
Autorova ustanovaHrvatski veterinarski institut
Autorova ustanovaInstitut Ruđer Bošković
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
(1) Background: Chronic spontaneous urticaria (CSU) has been linked to the dysbiosis of the gut microbiota. Furthermore, various studies have highlighted the anti-inflammatory properties of short-chain fatty acids (SCFAs), whose production is primarily regulated by the gut microbiota. However, only a few studies have investigated the role of major SCFA producers, such as Lachnospiraceae, in skin inflammatory diseases. (2) Goal: This study aimed to compare the abundance of Lachnospiraceae between CSU patients and healthy controls (HCs). (3) Material and methods: In this case–control study, 16S rRNA sequencing was performed to compare the composition of the gut microbiome between 22 CSU patients and 23 HCs. (4) Results: Beta-diversity revealed significant clustering (p < 0.05) between the CSU patients and HCs. Alpha diversity in the CSU group was significantly decreased according to the Evenness index (p < 0.05). The linear discriminant analysis effect size (LEfSe) identified the significant depletion of the Lachnospiraceae family in CSU patients. (5) Conclusion: Our study revealed the dysbiosis of the gut microbiota in CSU patients, including decreased levels of Lachnospiraceae members, responsible for SCFA production, suggesting that SCFAs may contribute to immune dysfunction in the pathogenesis of CSU. We speculate that the modulation of SCFAs could serve as a prospective additional option in CSU treatment.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaLife
Brojčani podacivol. 13, br. 6, 1280
e-ISSN2075-1729
DOIhttps://doi.org/10.3390/life13061280
URN:NBNurn:nbn:hr:127:290626
Datum objave publikacije2023-05-30
URL dokumentahttps://www.mdpi.com/2075-1729/13/6/1280
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-07-14 11:25:04