prikaz prve stranice dokumenta DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa
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DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa
International Journal of Molecular Sciences, 21 (2020), 18; 6853. https://doi.org/10.3390/ijms21186853
Milutin Gašperov, Nina; Sabol, Ivan; Božinović, Ksenija; Dediol, Emil; Mravak-Stipetić, Marinka; Licastro, Danilo; Dal Monego, Simeone; Grce, Magdalena

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Milutin Gašperov, N., Sabol, I., Božinović, K., Dediol, E., Mravak Stipetić, M., Licastro, D. ... Grce, M. (2020). DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa. International Journal of Molecular Sciences, 21. (18). doi: 10.3390/ijms21186853

Milutin Gašperov, Nina, et al. "DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa." International Journal of Molecular Sciences, vol. 21, br. 18, 2020. https://doi.org/10.3390/ijms21186853

Milutin Gašperov, Nina, Ivan Sabol, Ksenija Božinović, Emil Dediol, Marinka Mravak Stipetić, Danilo Licastro, Simeone Dal Monego i Magdalena Grce. "DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa." International Journal of Molecular Sciences 21, br. 18 (2020). https://doi.org/10.3390/ijms21186853

Milutin Gašperov, N., et al. (2020) 'DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa', International Journal of Molecular Sciences, 21(18). doi: 10.3390/ijms21186853

Milutin Gašperov N, Sabol I, Božinović K, Dediol E, Mravak Stipetić M, Licastro D, i sur.. DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa. International Journal of Molecular Sciences [Internet]. 18.09.2020. [pristupljeno 19.04.2024.];21(18). doi: 10.3390/ijms21186853

N. Milutin Gašperov, et al., "DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa", International Journal of Molecular Sciences, vol. 21, br. 18, Rujan 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:688471. [Citirano: 19.04.2024.]

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Naslov (engleski)DNA Methylome Distinguishes Head and Neck Cancer from Potentially Malignant Oral Lesions and Healthy Oral Mucosa
AutorNina Milutin Gašperov
AutorIvan Sabol
AutorKsenija Božinović
AutorEmil Dediol
AutorMarinka Mravak-Stipetić
AutorDanilo Licastro
AutorSimeone Dal Monego
AutorMagdalena Grce
Autorova ustanovaInstitut Ruđer Bošković
Autorova ustanova(Klinički bolnički centar Zagreb)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Dentalna medicina
Sažetak (engleski)
There is a strong need to find new, good biomarkers of head and neck squamous cell carcinoma (HNSCC) because of the bad prognoses and high mortality rates. The aim of this study was to identify the potential biomarkers in HNSCC that have differences in their DNA methylome and potentially premalignant oral lesions, in comparison to healthy oral mucosa. In this study, 32 oral samples were tested: nine healthy oral mucosae, 13 HNSCC, and 10 oral lesions for DNA methylation by the Infinium MethylationEPIC BeadChip. Our findings showed that a panel of genes significantly hypermethylated in their promoters or specific sites in HNSCC samples in comparison to healthy oral samples, which are mainly oncogenes, receptor, and transcription factor genes, or genes included in cell cycle, transformation, apoptosis, and autophagy. A group of hypomethylated genes in HNSCC, in comparison to healthy oral mucosa, are mainly involved in the host immune response and transcriptional regulation. The results also showed significant differences in gene methylation between HNSCC and potentially premalignant oral lesions, as well as differently methylated genes that discriminate between oral lesions and healthy mucosa. The given methylation panels point to novel potential biomarkers for early diagnostics of HNSCC, as well as potentially premalignant oral lesions.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 21, br. 18, 6853
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms21186853
URN:NBNurn:nbn:hr:127:688471
Datum objave publikacije2020-09-18
URL dokumentahttps://www.mdpi.com/1422-0067/21/18/6853
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-11-10 12:44:57