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Heparan Sulfate Glycosaminoglycan Is Predicted to Stabilize Inflammatory Infiltrate Formation and RANKL/OPG Ratio in Severe Periodontitis in Humans
Bioengineering, 9 (2022), 10; 566. https://doi.org/10.3390/bioengineering9100566
Duplančić, Roko; Roguljić, Marija; Božić, Darko; Kero, Darko

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Duplančić, R., Roguljić, M., Božić, D. i Kero, D. (2022). Heparan Sulfate Glycosaminoglycan Is Predicted to Stabilize Inflammatory Infiltrate Formation and RANKL/OPG Ratio in Severe Periodontitis in Humans. Bioengineering, 9. (10). doi: 10.3390/bioengineering9100566

Duplančić, Roko, et al. "Heparan Sulfate Glycosaminoglycan Is Predicted to Stabilize Inflammatory Infiltrate Formation and RANKL/OPG Ratio in Severe Periodontitis in Humans." Bioengineering, vol. 9, br. 10, 2022. https://doi.org/10.3390/bioengineering9100566

Duplančić, Roko, Marija Roguljić, Darko Božić i Darko Kero. "Heparan Sulfate Glycosaminoglycan Is Predicted to Stabilize Inflammatory Infiltrate Formation and RANKL/OPG Ratio in Severe Periodontitis in Humans." Bioengineering 9, br. 10 (2022). https://doi.org/10.3390/bioengineering9100566

Duplančić, R., et al. (2022) 'Heparan Sulfate Glycosaminoglycan Is Predicted to Stabilize Inflammatory Infiltrate Formation and RANKL/OPG Ratio in Severe Periodontitis in Humans', Bioengineering, 9(10). doi: 10.3390/bioengineering9100566

Duplančić R, Roguljić M, Božić D, Kero D. Heparan Sulfate Glycosaminoglycan Is Predicted to Stabilize Inflammatory Infiltrate Formation and RANKL/OPG Ratio in Severe Periodontitis in Humans. Bioengineering [Internet]. 18.10.2022. [pristupljeno 17.04.2024.];9(10). doi: 10.3390/bioengineering9100566

R. Duplančić, M. Roguljić, D. Božić i D. Kero, "Heparan Sulfate Glycosaminoglycan Is Predicted to Stabilize Inflammatory Infiltrate Formation and RANKL/OPG Ratio in Severe Periodontitis in Humans", Bioengineering, vol. 9, br. 10, Listopad 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:109850. [Citirano: 17.04.2024.]

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Naslov (engleski)Heparan Sulfate Glycosaminoglycan Is Predicted to Stabilize Inflammatory Infiltrate Formation and RANKL/OPG Ratio in Severe Periodontitis in Humans
AutorRoko Duplančić
AutorMarija Roguljić
AutorDarko Božić
AutorDarko Kero
Autorova ustanovaSveučilište u Splitu
Autorova ustanova(Klinički bolnički centar Split)
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Dentalna medicina
Parodontologija
Sažetak (engleski)
Since chronically inflamed periodontal tissue exhibits extracellular matrix (ECM) degradation, the possible alternative to standard periodontitis treatment is to restore ECM by supplementing its components, including heparan sulfate glycosaminoglycan (HS GAG). Supplementation of the degraded ECM with synthetic derivatives of HS GAGs has been shown to be effective for periodontal tissue regeneration in experimental animal models of periodontitis. However, the potential of HS GAG supplementation for the treatment of periodontal disease in humans is still unknown. Here, we used a statistical model to investigate the role of HS GAG on inflammatory infiltrate formation and alveolar bone resorption in humans with severe periodontitis. The model was based on data from immunofluorescence staining (IF) of human gingiva samples, and reconstruction of a subset of HS GAG -related proteins from STRING reactome database. According to predictions, increased expression of native HS GAG might stabilize the accumulation of gingival inflammatory infiltrate (represented by the general inflammatory cell marker CD45) and alveolar bone resorption (represented by Receptor Activator of Nuclear ΚΒ ligand (RANKL) and osteoprotegerin (OPG) ratio) but could not restore them to healthy tissue levels. Therefore, supplementation of native HS GAG may be of limited benefits for the treatment of sever periodontitis in humans.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBioengineering
Brojčani podacivol. 9, br. 10, 566
e-ISSN2306-5354
DOIhttps://doi.org/10.3390/bioengineering9100566
URN:NBNurn:nbn:hr:127:109850
Datum objave publikacije2022-10-18
URL dokumentahttps://www.mdpi.com/2306-5354/9/10/566
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-11-10 10:16:42