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Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients
Journal of Clinical Medicine, 10 (2021), 18; 4222. https://doi.org/10.3390/jcm10184222
Paštrović, Frane; Lucijanić, Marko; Atić, Armin; Stojić, Josip; Barišić Jaman, Mislav; Tješić Drinković, Ida; Zelenika, Marko; Milošević, Marko; Medić, Barbara; Lončar, Jelena; Mijić, Maja; Filipec Kanižaj, Tajana; Kralj, Dominik; Lerotić, Ivan; Virović Jukić, Lucija; Ljubičić, Neven; Luetić, Krešimir; Grgić, Dora; Majerović, Matea; Ostojić, Rajko; Krznarić, Željko; Lukšić, Ivica; Piskač Živković, Nevenka; Kereš, Tatjana; Grabovac, Vlatko; Peršec, Jasminka; Baršić, Bruno; Grgurević, Ivica Više autora...

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Paštrović, F., Lucijanić, M., Atić, A., Stojić, J., Barišić Jaman, M., Tješić Drinković, I. ... Grgurević, I. (2021). Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients. Journal of Clinical Medicine, 10. (18). doi: 10.3390/jcm10184222

Paštrović, Frane, et al. "Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients." Journal of Clinical Medicine, vol. 10, br. 18, 2021. https://doi.org/10.3390/jcm10184222

Paštrović, Frane, Marko Lucijanić, Armin Atić, Josip Stojić, Mislav Barišić Jaman, Ida Tješić Drinković, Marko Zelenika, et al. "Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients." Journal of Clinical Medicine 10, br. 18 (2021). https://doi.org/10.3390/jcm10184222

Paštrović, F., et al. (2021) 'Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients', Journal of Clinical Medicine, 10(18). doi: 10.3390/jcm10184222

Paštrović F, Lucijanić M, Atić A, Stojić J, Barišić Jaman M, Tješić Drinković I, i sur.. Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients. Journal of Clinical Medicine [Internet]. 17.09.2021. [pristupljeno 09.12.2024.];10(18). doi: 10.3390/jcm10184222

F. Paštrović, et al., "Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients", Journal of Clinical Medicine, vol. 10, br. 18, Rujan 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:753957. [Citirano: 09.12.2024.]

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Podaci o radu
Naslov (engleski)Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients
AutorFrane Paštrović
AutorMarko Lucijanić
AutorArmin Atić
AutorJosip Stojić
AutorMislav Barišić Jaman
AutorIda Tješić Drinković
AutorMarko Zelenika
AutorMarko Milošević
AutorBarbara Medić
AutorJelena Lončar
AutorMaja Mijić
AutorTajana Filipec Kanižaj
AutorDominik Kralj
AutorIvan Lerotić
AutorLucija Virović Jukić
AutorNeven Ljubičić
AutorKrešimir Luetić
AutorDora Grgić
AutorMatea Majerović
AutorRajko Ostojić
AutorŽeljko Krznarić
MBZ: 75865
AutorIvica Lukšić
AutorNevenka Piskač Živković
AutorTatjana Kereš
AutorVlatko Grabovac
AutorJasminka Peršec
AutorBruno Baršić
AutorIvica Grgurević
Autorova ustanova(Klinička bolnica Merkur)
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Background: Derangement of liver blood tests (LBT) is frequent in patients with Coronavirus disease 2019 (COVID-19). We aimed to evaluate (a) the prevalence of deranged LBT as well as their association with (b) clinical severity at admission and (c) 30-day outcomes among the hospitalized patients with COVID-19. Methods: Consecutive patients with COVID-19 hospitalized in the regional referral center over the 12-month period were included. Clinical severity of COVID-19 at hospital admission and 30-day outcomes (need for intensive care, mechanical ventilation, or death) were analyzed. Results: Derangement of LBT occurred in 2854/3812 (74.9%) of patients, most frequently due to elevation of AST (61.6%), GGT (46.1%) and ALT (33.4%). Elevated AST, ALT, GGT and low albumin were associated with more severe disease at admission. However, in multivariate Cox regression analysis, when adjusted for age, sex, obesity and presence of chronic liver disease, only AST remained associated with the risk of dying (HR 1.5081 and 2.1315, for elevations 1–3 × ULN and >3 × ULN, respectively) independently of comorbidity burden and COVID-19 severity at admission. Patients with more severe liver injury more frequently experienced defined adverse outcomes. Conclusions: Deranged LBTs are common among patients hospitalized with COVID-19 and might be used as predictors of adverse clinical outcomes.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Clinical Medicine
Brojčani podacivol. 10, br. 18, 4222
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm10184222
URN:NBNurn:nbn:hr:127:753957
Datum objave publikacije2021-09-17
URL dokumentahttps://www.mdpi.com/2077-0383/10/18/4222
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-11-07 10:55:13