prikaz prve stranice dokumenta Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer
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Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer
Genes, 13 (2022), 2; 383. https://doi.org/10.3390/genes13020383
Ljubić, Sven; Sermek, Antonio; Prgomet Sečan, Angela; Prpić, Marin; Jakšić, Blanka; Murgić, Jure; Fröbe, Ana; Ugarković, Đurđica; Feliciello, Isidoro

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Ljubić, S., Sermek, A., Prgomet Sečan, A., Prpić, M., Jakšić, B., Murgić, J. ... Feliciello, I. (2022). Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer. Genes, 13. (2). doi: 10.3390/genes13020383

Ljubić, Sven, et al. "Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer." Genes, vol. 13, br. 2, 2022. https://doi.org/10.3390/genes13020383

Ljubić, Sven, Antonio Sermek, Angela Prgomet Sečan, Marin Prpić, Blanka Jakšić, Jure Murgić, Ana Fröbe, Đurđica Ugarković i Isidoro Feliciello. "Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer." Genes 13, br. 2 (2022). https://doi.org/10.3390/genes13020383

Ljubić, S., et al. (2022) 'Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer', Genes, 13(2). doi: 10.3390/genes13020383

Ljubić S, Sermek A, Prgomet Sečan A, Prpić M, Jakšić B, Murgić J, i sur.. Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer. Genes [Internet]. 20.02.2022. [pristupljeno 19.04.2025.];13(2). doi: 10.3390/genes13020383

S. Ljubić, et al., "Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer", Genes, vol. 13, br. 2, Veljača 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:352964. [Citirano: 19.04.2025.]

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Naslov (engleski)Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer
AutorSven Ljubić
AutorAntonio Sermek
AutorAngela Prgomet Sečan
AutorMarin Prpić
AutorBlanka Jakšić
AutorJure Murgić
AutorAna Fröbe
AutorĐurđica Ugarković
AutorIsidoro Feliciello
Autorova ustanovaInstitut Ruđer Bošković
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
The aberrant overexpression of alpha satellite DNA is characteristic of many human cancers including prostate cancer; however, it is not known whether the change in the alpha satellite RNA amount occurs in the peripheral tissues of cancer patients, such as blood. Here, we analyse the level of intracellular alpha satellite RNA in the whole blood of cancer prostate patients at different stages of disease and compare it with the levels found in healthy controls. Our results reveal a significantly increased level of intracellular alpha satellite RNA in the blood of metastatic cancers patients, particularly those with metastatic castration-resistant prostate cancer relative to controls. In the blood of patients with localised tumour, no significant change relative to the controls was detected. Our results show a link between prostate cancer pathogenesis and blood intracellular alpha satellite RNA levels. We discuss the possible mechanism which could lead to the increased level of blood intracellular alpha satellite RNA at a specific metastatic stage of prostate cancer. Additionally, we analyse the clinically accepted prostate cancer biomarker PSA in all samples and discuss the possibility that alpha satellite RNA can serve as a novel prostate cancer diagnostic blood biomarker.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaGenes
Brojčani podacivol. 13, br. 2, 383
e-ISSN2073-4425
DOIhttps://doi.org/10.3390/genes13020383
URN:NBNurn:nbn:hr:127:352964
Datum objave publikacije2022-02-20
URL dokumentahttps://www.mdpi.com/2073-4425/13/2/383
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-11 10:23:40