Naslov Kvaliteta života bolesnika s kroničnom neuropatskom neodontogenom orofacijalnom boli Naslov (engleski) Quality of life in patients with chronic neuropathic nonodontogenic orofacial pain Autor Duška Šklebar Mentor Vanja Bašić Kes (mentor)Član povjerenstva Vesna Šerić (predsjednik povjerenstva)Član povjerenstva Darko Macan (član povjerenstva)Član povjerenstva Zlatko Trkanjec (član povjerenstva)Član povjerenstva Katarina Šakić (član povjerenstva)Ustanova koja je dodijelila Sveučilište u Zagrebu Datum i država obrane 2014-09-16, Hrvatska Znanstveno / umjetničko BIOMEDICINA I ZDRAVSTVO Univerzalna decimalna klasifikacijaUDC ) 616.31 - Stomatologija Sažetak Kronična neuropatska neodontogena orofacijalna bol (OFP) vodeći je simptom širokoga spektra bolesti, a može egzistirati i samostalno, bez drugih kliničkih znakova ili simptoma, uz uredne radiološke ili laboratorijske nalaze. OFP može uzrokovati emocionalne, psihološke i socijalne poremećaje i tako značajno utjecati na kvalitetu života oboljele osobe.
Cilj je istraživanja usporedba procijenjene, sa zdravljem povezane kvalitete života, i stupnja depresije ispitanika s OFP, s rezultatima zdravih ispitanika kontrolne skupine.
Ispitanici i metode: u studiju je uključeno 100 ispitanika prosječne dobi 56,95(±13,58), s kliničkom dijagnozom OFP, u trajanju od najmanje šest mjeseci, i 119 zdravih ispitanika prosječne dobi 57,21(±13,87), koji su bili kontrolna skupina. Primjenjen je standardni dijagnostički protokol: 1) demografski podaci; 2) procjena nazočnosti neuropatske boli Leedskim upitnikom neuropatskih znakova i simptoma (LANSS); 3) određivanje intenziteta boli vizualno analognom ljestvicom (VAS) u trenutku ispitivanja te tijekom protekloga mjeseca; 4) procjena emocionalnoga statusa Beckovim inventarom depresije II (BDI-II); 5) procjena o zdravlju ovisne kvalitete života SF-36 upitnikom.
Rezultati: prosječan LANSS rezultat za skupinu oboljelih iznosi 17,18, a za kontrolnu skupinu 0. Prosječan rezultat BDI-II u skupini oboljelih je 18,31, prema 5,87 u kontrolnoj skupini. Mann-Whitneyjevim U testom svaka od devet kategorija koje mjeri SF-36 statistički se signifikantno razlikuje između bolesnih i zdravih ispitanika. U svim kategorijama, osim jedne (vitalnost), kontrolna skupina ima viši indeks u odnosu na skupinu s OFP. Rezultat kontrolne skupine veći je od 60% u šest od devet kategorija, dok skupina oboljelih ne prelazi granicu od 60% niti u jednoj kategoriji.
Zaključak: kronična neuropatska neodontogena orofacijalna bol uzrokuje depresiju i utječe na gotovo sve odrednice kvalitete života, mjerene SF-36 upitnikom. Postoji jaka povezanost između depresije i niske kvalitete života oboljelih od OFP.
Sažetak (engleski) Background: Chronic neuropathic nonodontogenic orofacial pain (OFP) is the leading symptom of a wide range of diseases, which can exist independently, without other clinical signs or symptoms and without abormalities in radiological or laboratory findings. OFP is a disease which should be treated adequately. Its successful treatment depends on the early diagnostics and understanding of the mechanisms of its occurrence. The most frequent clinical entity in our sample was nonodontogenic trigeminal neuralgia, the fifth cranial nerve disorder characterized by bouts of intense, sharp pain which usually affects one or two branches of the nerve on one side of the face. In most cases, the exact cause of trigeminal neuralgia has not been completely clarified. OFP causes emotional, psychological and social disorders, which can significantly affect the quality of life of the affected person.
Aim of study: The aim of the research is to compare the estimated health-related quality of life and the degree of depression of patients with OFP with healthy control subjects, using a validated Croatian version of the SF-36 Health Survey Questionnaire and the Beck Depression Inventory II.
Patients and Methods: The controlled cross-sectional study included 100 patients aged between 18 and 75, with the clinical diagnosis of OFP in duration of at least six months (72 females and 28 males), and 119 healthy subjects (73 females and 46 males) as a control group. A standardized diagnostic protocol was applied to both the patients and the control group: 1) demographic data and quantitative estimate of pain on the visual analog scale (VAS); 2) evaluation of presence of neuropathic pain measured by the Leeds Assessment of Neuropathic Signs and Symptoms (LANSS); 3) evaluation of emotional status using the Beck Depression Inventory II, and 4) assessment of health-related quality of life using the SF-36 Questionnaire. The Kolmogorov–Smirnov Test analyzed the normality of data distribution, and, in keeping with the results, suitable nonparametric tests were used in further data processing. Quantitative data were shown through medians and interquartile range, while the nominal and categorical data were presented through absolute frequencies and the corresponding relative frequencies. The difference in the continued values between the groups
were analyzed using Mann-Whitney U Test, while the differences between the nominal and categorical values were analyzed using Chi-Square Test. Spearman's rank correlation coefficient between individual clinical parameters was calculated. All P values smaller than 0.05 were considered statistically significant.
Results: The average LANSS score for the patients was 17.18, and for the control group 0. The average BDI-II score for the patients was 18.31, as opposed to 5.87 for the control group. The Mann-Whitney U Test for each of the nine categories that measure SF-36, shows statistically significant difference between the affected and healthy subjects. In all the categories except one (Vitality), the control group has a higher index than the group with OFP. The result of the control group was equal or greater than 60% of the possible overall result in seven out of nine categories, while the treatment group did not exceed the limit of 60% in any of the categories. A statistically significant correlation was noted between the degree of depression and the SF-36 domains of Physical Functioning (PF), Body Pain (BP), General Health Perception (GH), Vitality (VT), Social Functioning (SF), Role Emotional (RE) and Mental Health (MH). No statistically significant correlation was proven between the degree of depression and the domains of Role Physical (RP) and Health Transition (HT).
Conclusion: Chronic neuropathic nonodontogenic orofacial pain causes depression and affects almost all the determinants of quality of life measured by SF-36 Questionnaire. There is a strong correlation between depression and low quality of life in patients with OFP.
Ključne riječi
kronična neodontogena orofacijalna bol
kronična neuropatska orofacijalna bol
depresija
kvaliteta života povezana sa zdravljem
Ključne riječi (engleski)
chronic nonodontogenic orofacial pain
chronic neuropathic orofacial pain
depression
health-related quality of life
Jezik hrvatski URN:NBN urn:nbn:hr:127:404742 Studijski program Naziv: Dentalna medicina Vrsta resursa Tekst Način izrade datoteke Izvorno digitalna Prava pristupa Otvoreni pristup Uvjeti korištenja Datum i vrijeme pohrane 2017-03-15 11:15:42
