prikaz prve stranice dokumenta GLI Transcriptional Targets S100A7 and KRT16 Show Upregulated Expression Patterns in Epidermis Overlying the Tumor Mass in Melanoma Samples
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GLI Transcriptional Targets S100A7 and KRT16 Show Upregulated Expression Patterns in Epidermis Overlying the Tumor Mass in Melanoma Samples
International Journal of Molecular Sciences, 25 (2024), 11; 6084. https://doi.org/10.3390/ijms25116084
Kurtović, Matea; Piteša, Nikolina; Čonkaš, Josipa; Hajpek, Helena; Vučić, Majda; Musani, Vesna; Ozretić, Petar; Sabol, Maja

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Kurtović, M., Piteša, N., Čonkaš, J., Hajpek, H., Vučić, M., Musani, V. ... Sabol, M. (2024). GLI Transcriptional Targets S100A7 and KRT16 Show Upregulated Expression Patterns in Epidermis Overlying the Tumor Mass in Melanoma Samples. International Journal of Molecular Sciences, 25. (11). doi: 10.3390/ijms25116084

Kurtović, Matea, et al. "GLI Transcriptional Targets S100A7 and KRT16 Show Upregulated Expression Patterns in Epidermis Overlying the Tumor Mass in Melanoma Samples." International Journal of Molecular Sciences, vol. 25, br. 11, 2024. https://doi.org/10.3390/ijms25116084

Kurtović, Matea, Nikolina Piteša, Josipa Čonkaš, Helena Hajpek, Majda Vučić, Vesna Musani, Petar Ozretić i Maja Sabol. "GLI Transcriptional Targets S100A7 and KRT16 Show Upregulated Expression Patterns in Epidermis Overlying the Tumor Mass in Melanoma Samples." International Journal of Molecular Sciences 25, br. 11 (2024). https://doi.org/10.3390/ijms25116084

Kurtović, M., et al. (2024) 'GLI Transcriptional Targets S100A7 and KRT16 Show Upregulated Expression Patterns in Epidermis Overlying the Tumor Mass in Melanoma Samples', International Journal of Molecular Sciences, 25(11). doi: 10.3390/ijms25116084

Kurtović M, Piteša N, Čonkaš J, Hajpek H, Vučić M, Musani V, i sur.. GLI Transcriptional Targets S100A7 and KRT16 Show Upregulated Expression Patterns in Epidermis Overlying the Tumor Mass in Melanoma Samples. International Journal of Molecular Sciences [Internet]. 31.05.2024. [pristupljeno 14.02.2025.];25(11). doi: 10.3390/ijms25116084

M. Kurtović, et al., "GLI Transcriptional Targets S100A7 and KRT16 Show Upregulated Expression Patterns in Epidermis Overlying the Tumor Mass in Melanoma Samples", International Journal of Molecular Sciences, vol. 25, br. 11, Svibanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:127:880572. [Citirano: 14.02.2025.]

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Podaci o radu
Naslov (engleski)GLI Transcriptional Targets S100A7 and KRT16 Show Upregulated Expression Patterns in Epidermis Overlying the Tumor Mass in Melanoma Samples
AutorMatea Kurtović
AutorNikolina Piteša
AutorJosipa Čonkaš
AutorHelena Hajpek
AutorMajda Vučić
AutorVesna Musani
AutorPetar Ozretić
AutorMaja Sabol
Autorova ustanovaInstitut Ruđer Bošković
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Autorova ustanovaSveučilište u Zagrebu
Stomatološki fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Although not completely understood, the role of the Hedgehog-GLI (HH-GLI) signaling pathway in melanoma and epithelial skin tumors has been reported before. In this study, we confirmed in various melanoma cell line models that keratin 16 (KRT16) and S100 Calcium-Binding Protein A7 (S100A7) are transcriptional targets of GLI Family Zinc Finger (GLI) proteins. Besides their important role in protecting and maintaining the epidermal barrier, keratins are somehow tightly connected with the S100 family of proteins. We found that stronger expression of KRT16 indeed corresponds to stronger expression of S100A7 in our clinical melanoma samples. We also report a trend regarding staining of GLI1, which corresponds to stronger staining of GLI3, KRT16, and S100A7 proteins. The most interesting of our findings is that all the proteins are detected specifically in the epidermis overlying the tumor, but rarely in the tumor itself. The examined proteins were also not detected in the healthy epidermis at the edges of the sample, suggesting that the staining is specific to the epidermis overlaying the tumor mass. Of all proteins, only S100A7 demonstrated a statistically significant trend regarding tumor staging and staining intensity. Results from our clinical samples prove that immune infiltration is an important feature of melanoma. Pigmentophages and tumor-infiltrating lymphocytes (TIL) demonstrate a significant association with tumor stage, while mononuclear cells are equally present in all stages. For S100A7, we found an association between the number of TILs and staining intensity. Considering these new findings presented in our study, we suggest a more detailed examination of the possible role of the S100A7 protein as a biomarker in melanoma.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 25, br. 11, 6084
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms25116084
URN:NBNurn:nbn:hr:127:880572
Datum objave publikacije2024-05-31
URL dokumentahttps://www.mdpi.com/1422-0067/25/11/6084
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2024-06-27 08:41:13