The Relationship between Tumor Budding and Tumor Deposits in Patients with Stage III Colorectal Carcinoma

Znanstveni rad - Izvorni znanstveni rad

• Autor: Zdenko Bilić
• Autor: Mario Zovak
• Autor: Goran Glavčić
• Autor: Dubravka Mužina
• Autor: Amir Ibukić
• Autor: Andro Košec
• Autor: Davor Tomas
• Autor: Alma Demirović
• Autorova ustanova: (Klinički bolnički centar Sestre milosrdnice)
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet
• Autorova ustanova: Sveučilište u Zagrebu; Stomatološki fakultet
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti

Sažetak (engleski)

Background/Objectives: Recently, some new morphological features of colorectal cancer have been discovered as important prognostic factors; in this paper, we study the relationship between tumor budding (TB) and tumor deposits (TDs). Methods: The retrospective cohort study included 90 patients with pathohistologically confirmed stage III CRC who were treated with radical surgical resection. All hematoxylin and eosin (H and E)-stained slides from each patient were reviewed, and histological parameters were recorded. The samples were divided into two groups with similar sizes: a group without TDs (N = 51) and a control group with TDs (N = 39). The presence and TB grade were further analyzed in these groups and compared with other clinical and histological features. Results: The prevalence of TB in the investigated cohort was unexpectedly high (94.4%). Overall, there were 23 (25.6%) Bd1, 20 (22.2%) Bd2, and 47 (52.2%) Bd3 cases. The presence of TDs was significantly associated with a higher number of TB (p < 0.001, OR 16.3) and, consequently, with a higher TB grade (p = 0.004, OR 11.04). A higher TB grade (p = 0.001, HR 2.28; 95% CI 1.93–4.76) and a growing number of TDs (p = 0.014, HR 1.52; 95% CI 1.09–2.1) were statistically significantly associated with shorter survival. Conclusions: TDs appear more often in patients with higher TB grades in stage III CRC. A higher TB grade and a growing number of TDs were statistically significantly associated with shorter overall survival. These results could give additional emphasis to the importance of TB as an adverse prognostic factor since a strong relationship with TDs has been demonstrated.

• Ključne riječi (engleski): colorectal carcinoma; tumor budding; tumor deposits; epithelial-mesenchymal transition
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - međunarodna recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Journal of Clinical Medicine
• Brojčani podaci: vol. 13, br. 9, 2583
• e-ISSN: 2077-0383
• DOI: https://doi.org/10.3390/jcm13092583
• URN:NBN: urn:nbn:hr:127:018284
• Datum objave publikacije: 2024-04-27
• URL dokumenta: https://www.mdpi.com/2077-0383/13/9/2583
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-05-23 08:42:09