prikaz prve stranice dokumenta Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer
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Scientific paper - Original scientific paper
Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer
Genes, 13 (2022), 2; 383. https://doi.org/10.3390/genes13020383
Ljubić, Sven; Sermek, Antonio; Prgomet Sečan, Angela; Prpić, Marin; Jakšić, Blanka; Murgić, Jure; Fröbe, Ana; Ugarković, Đurđica; Feliciello, Isidoro

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Ljubić, S., Sermek, A., Prgomet Sečan, A., Prpić, M., Jakšić, B., Murgić, J. ... Feliciello, I. (2022). Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer. Genes, 13. (2). doi: 10.3390/genes13020383

Ljubić, Sven, et al. "Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer." Genes, vol. 13, no. 2, 2022. https://doi.org/10.3390/genes13020383

Ljubić, Sven, Antonio Sermek, Angela Prgomet Sečan, Marin Prpić, Blanka Jakšić, Jure Murgić, Ana Fröbe, Đurđica Ugarković and Isidoro Feliciello. "Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer." Genes 13, no. 2 (2022). https://doi.org/10.3390/genes13020383

Ljubić, S., et al. (2022) 'Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer', Genes, 13(2). doi: 10.3390/genes13020383

Ljubić S, Sermek A, Prgomet Sečan A, Prpić M, Jakšić B, Murgić J, and sur.. Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer. Genes [Internet]. 2022 February 20 [cited 2025 April 14];13(2). doi: 10.3390/genes13020383

S. Ljubić, et al., "Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer", Genes, vol. 13, no. 2, February 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:352964. [Accessed: 14 April 2025]

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Metadata
Title (english)Alpha Satellite RNA Levels Are Upregulated in the Blood of Patients with Metastatic Castration-Resistant Prostate Cancer
AuthorSven Ljubić
AuthorAntonio Sermek
AuthorAngela Prgomet Sečan
AuthorMarin Prpić
AuthorBlanka Jakšić
AuthorJure Murgić
AuthorAna Fröbe
AuthorĐurđica Ugarković
AuthorIsidoro Feliciello
Author's institutionRuđer Bošković Institute
Author's institution(Sestre milosrdnice University Hospital Center)
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The aberrant overexpression of alpha satellite DNA is characteristic of many human cancers including prostate cancer; however, it is not known whether the change in the alpha satellite RNA amount occurs in the peripheral tissues of cancer patients, such as blood. Here, we analyse the level of intracellular alpha satellite RNA in the whole blood of cancer prostate patients at different stages of disease and compare it with the levels found in healthy controls. Our results reveal a significantly increased level of intracellular alpha satellite RNA in the blood of metastatic cancers patients, particularly those with metastatic castration-resistant prostate cancer relative to controls. In the blood of patients with localised tumour, no significant change relative to the controls was detected. Our results show a link between prostate cancer pathogenesis and blood intracellular alpha satellite RNA levels. We discuss the possible mechanism which could lead to the increased level of blood intracellular alpha satellite RNA at a specific metastatic stage of prostate cancer. Additionally, we analyse the clinically accepted prostate cancer biomarker PSA in all samples and discuss the possibility that alpha satellite RNA can serve as a novel prostate cancer diagnostic blood biomarker.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleGenes
Numberingvol. 13, no. 2, 383
e-ISSN2073-4425
DOIhttps://doi.org/10.3390/genes13020383
URN:NBNurn:nbn:hr:127:352964
Publication2022-02-20
Document URLhttps://www.mdpi.com/2073-4425/13/2/383
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-03-11 10:23:40