The Relationship between Tumor Budding and Tumor Deposits in Patients with Stage III Colorectal Carcinoma

Scientific paper - Original scientific paper

• Author: Zdenko Bilić
• Author: Mario Zovak
• Author: Goran Glavčić
• Author: Dubravka Mužina
• Author: Amir Ibukić
• Author: Andro Košec
• Author: Davor Tomas
• Author: Alma Demirović
• Author's institution: (Sestre milosrdnice University Hospital Center)
• Author's institution: University of Zagreb; School of Medicine
• Author's institution: University of Zagreb; School of Dental Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

Background/Objectives: Recently, some new morphological features of colorectal cancer have been discovered as important prognostic factors; in this paper, we study the relationship between tumor budding (TB) and tumor deposits (TDs). Methods: The retrospective cohort study included 90 patients with pathohistologically confirmed stage III CRC who were treated with radical surgical resection. All hematoxylin and eosin (H and E)-stained slides from each patient were reviewed, and histological parameters were recorded. The samples were divided into two groups with similar sizes: a group without TDs (N = 51) and a control group with TDs (N = 39). The presence and TB grade were further analyzed in these groups and compared with other clinical and histological features. Results: The prevalence of TB in the investigated cohort was unexpectedly high (94.4%). Overall, there were 23 (25.6%) Bd1, 20 (22.2%) Bd2, and 47 (52.2%) Bd3 cases. The presence of TDs was significantly associated with a higher number of TB (p < 0.001, OR 16.3) and, consequently, with a higher TB grade (p = 0.004, OR 11.04). A higher TB grade (p = 0.001, HR 2.28; 95% CI 1.93–4.76) and a growing number of TDs (p = 0.014, HR 1.52; 95% CI 1.09–2.1) were statistically significantly associated with shorter survival. Conclusions: TDs appear more often in patients with higher TB grades in stage III CRC. A higher TB grade and a growing number of TDs were statistically significantly associated with shorter overall survival. These results could give additional emphasis to the importance of TB as an adverse prognostic factor since a strong relationship with TDs has been demonstrated.

• Keywords (english): colorectal carcinoma; tumor budding; tumor deposits; epithelial-mesenchymal transition
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review - international
• Publication version: Published version
• Journal title: Journal of Clinical Medicine
• Numbering: vol. 13, no. 9, 2583
• e-ISSN: 2077-0383
• DOI: https://doi.org/10.3390/jcm13092583
• URN:NBN: urn:nbn:hr:127:018284
• Publication: 2024-04-27
• Document URL: https://www.mdpi.com/2077-0383/13/9/2583
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-05-23 08:42:09