Dijagnostički i terapijski pristup dobroćudnim tumorima žlijezda slinovnica

master's thesis

• Title (english): Diagnostic and Therapeutic Approach to Benign Salivary Gland Tumours
• Author: Nives Tea Lovrić
• Mentor: Davor Vagić (mentor)
• Committee member: Davor Vagić (predsjednik povjerenstva)
• Committee member: Robert Trotić (član povjerenstva)
• Committee member: Goran Geber (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Chair of Otorhynolaringology); Zagreb
• Defense date and country: 2016-09-29, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Prosthetic Dentistry

Abstract

U usnoj šupljini nalaze se tri para velikih žlijezda slinovnica: parotidna,
submandibularna i sublingvalna te velik broj manjih žlijezdi, smještenih u
submukozi usne šupljine i ždrijela.
Većina svih tumora žlijezda slinovnica nastaje u parotidi i većina ih je benigna,
a sama žlijezda je važna zbog povezanosti s facijalnim živcem, što utječe na liječenje
i kvalitetu života.
Najčešći benigni tumor je pleomorfni adenom (miješani tumor) koji se
ponajprije pojavljuje u žena oko 40. godine života, a moguća je i njegova zloćudna
preobrazba (karcinom u pleomorfnom adenomu). Drugi najčešći je Warthinov tumor,
koji se pojavljuje u starijoj dobi, većinom u muškaraca u šestom desetljeću.
Benigni tumori klinički izgledaju kao pomične mase koje uzrokuju otekline,
najčešće su asimptomatski i rastu kroz dulje vrijeme.
Dijagnostika obuhvaća dobro uzetu anamnezu, inspekciju i palpaciju. U bitne
pretrage spadaju CT, UZV, MR sijalografija, scintigrafija te aspiracijska biopsija
tankom iglom (FNA).
Liječenje je isključivo kirurško. U slučaju dugotrajnog neliječenja može doći
do maligne transformacije ili do pojave recidiva u slučaju nepotpunog odstranjenja

Abstract (english)

There are three pairs of major salivary glands in the mouth: parotid,
submandibular and sublingual, and a large number of minor salivary glands, located
in the submucosa of the oral cavity and pharynx.
Most salivary gland tumours occur in the parotid, and are benign, and the gland
itself is very important due to its relation to the facial nerve, which affects the
treatment and the quality of life.
The most common benign tumour is pleomorphic adenoma (mixed tumour),
which primarily occurs in women around the age of 40, but its malignant
transformation is possible (carcinoma ex pleomorphic adenoma). The second most
common is Warthin tumour, which occurs in the elderly, mostly in men in their sixth
decade of life.
Clinically, benign tumours have apperance of a moving mass that causes
swelling; they are most often asymptomatic and grow over the long run.
A diagnosis includes thorough anamnesis, inspection and palaption. Important
tests include CT, ultrasonography, MRI sialography, scintigraphy and fine needle
aspiration biopsy (FNA).
The treatment is exclusively surgical. In case of a long-term nontreatment, it
can lead to malignant transformation and relapse if not removed completly.

• Keywords: žlijezde slinovnice; novotvorine
• Keywords (english): salivary gland diseases; neoplasms
• Language: croatian
• URN:NBN: urn:nbn:hr:127:360032
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-11-21 14:19:23