prikaz prve stranice dokumenta Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria
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Scientific paper - Original scientific paper
Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria
Life, 13 (2023), 6; 1280. https://doi.org/10.3390/life13061280
Ćesić, Diana; Lugović Mihić, Liborija; Ozretić, Petar; Lojkić, Ivana; Buljan, Marija; Šitum, Mirna; Zovak, Mario; Vidović, Dinko; Mijić, August; Galić, Nada; Tambić Andrašević, Arjana

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Ćesić, D., Lugović Mihić, L., Ozretić, P., Lojkić, I., Buljan, M., Šitum, M. ... Tambić Andrašević, A. (2023). Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria. Life, 13. (6). doi: 10.3390/life13061280

Ćesić, Diana, et al. "Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria." Life, vol. 13, no. 6, 2023. https://doi.org/10.3390/life13061280

Ćesić, Diana, Liborija Lugović Mihić, Petar Ozretić, Ivana Lojkić, Marija Buljan, Mirna Šitum, Mario Zovak, et al. "Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria." Life 13, no. 6 (2023). https://doi.org/10.3390/life13061280

Ćesić, D., et al. (2023) 'Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria', Life, 13(6). doi: 10.3390/life13061280

Ćesić D, Lugović Mihić L, Ozretić P, Lojkić I, Buljan M, Šitum M, and sur.. Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria. Life [Internet]. 2023 May 30 [cited 2024 April 28];13(6). doi: 10.3390/life13061280

D. Ćesić, et al., "Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria", Life, vol. 13, no. 6, May 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:290626. [Accessed: 28 April 2024]

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Metadata
Title (english)Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria
AuthorDiana Ćesić
AuthorLiborija Lugović Mihić
MBZ: 215056
AuthorPetar Ozretić
AuthorIvana Lojkić
AuthorMarija Buljan
AuthorMirna Šitum
AuthorMario Zovak
AuthorDinko Vidović
AuthorAugust Mijić
AuthorNada Galić
MBZ: 192110
AuthorArjana Tambić Andrašević
Author's institutionCroatian Veterinary Institute
Author's institutionRuđer Bošković Institute
Author's institution(Sestre milosrdnice University Hospital Center)
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
(1) Background: Chronic spontaneous urticaria (CSU) has been linked to the dysbiosis of the gut microbiota. Furthermore, various studies have highlighted the anti-inflammatory properties of short-chain fatty acids (SCFAs), whose production is primarily regulated by the gut microbiota. However, only a few studies have investigated the role of major SCFA producers, such as Lachnospiraceae, in skin inflammatory diseases. (2) Goal: This study aimed to compare the abundance of Lachnospiraceae between CSU patients and healthy controls (HCs). (3) Material and methods: In this case–control study, 16S rRNA sequencing was performed to compare the composition of the gut microbiome between 22 CSU patients and 23 HCs. (4) Results: Beta-diversity revealed significant clustering (p < 0.05) between the CSU patients and HCs. Alpha diversity in the CSU group was significantly decreased according to the Evenness index (p < 0.05). The linear discriminant analysis effect size (LEfSe) identified the significant depletion of the Lachnospiraceae family in CSU patients. (5) Conclusion: Our study revealed the dysbiosis of the gut microbiota in CSU patients, including decreased levels of Lachnospiraceae members, responsible for SCFA production, suggesting that SCFAs may contribute to immune dysfunction in the pathogenesis of CSU. We speculate that the modulation of SCFAs could serve as a prospective additional option in CSU treatment.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleLife
Numberingvol. 13, no. 6, 1280
e-ISSN2075-1729
DOIhttps://doi.org/10.3390/life13061280
URN:NBNurn:nbn:hr:127:290626
Publication2023-05-30
Document URLhttps://www.mdpi.com/2075-1729/13/6/1280
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-07-14 11:25:04