Primjena trombocitima obogaćenog fibrina u augmentativnim tehnikama čeljusti

master's thesis

• Author: Anja Bakaran
• Mentor: Dragana Gabrić (mentor)
• Committee member: Dragana Gabrić (predsjednik povjerenstva)
• Committee member: Ana Kotarac Knežević (član povjerenstva)
• Committee member: Nada Galić (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Department of Oral Surgery); Zagreb
• Defense date and country: 2016-09-20, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Oral Surgery

Abstract

Trombocitima obogaćen fibrin (engl. platelet rich fibrin, PRF) autologni je biomaterijal koji predstavlja drugu generaciju trombocitnih koncentrata. Tehniku uporabe PRF-a predstavili su u Francuskoj 2001. godine Choukroun i sur. Nasljednik je trombocitima obogaćene plazme (PRP) s višestrukim prednostima.
PRF se sastoji od trombocita, leukocitnih citokina, faktora rasta i fibrinske mrežice koja ih međusobno povezuje. Trombociti stvaraju trombocitni čep, tj. krvni ugrušak te potiču lučenje faktora rasta. Faktori rasta upravljaju proliferacijom, kemotaksijom, sintezom matriksa i morfogenezom tkiva. Otpuštanjem citokina i faktora rasta PRF potiče sintezu kolagena te formiranje kosti.
PRF nastaje samo centrifugiranjem krvi pacijenta bez uporabe dodatnih aditiva.
Primjenjuje se u parodontnoj, oralnoj, maksilofacijalnoj i plastičnoj kirurgiji te u otorinolaringologiji kao dodatno sredstvo u liječenju različitih oblika koštanih i sluzničkih defekata, trauma i infekcija.
Najveće su prednosti rada s PRF-om jednostavnost pripravka preparata, mali troškovi, dostupnost svakom pacijentu te minimalna trauma.

Abstract (english)

Platelet Rich Fibrin (engl. Platelet Rich Fibrin, PRF) is autologous biomaterial which represents the second generation of platelet concentrates. The technique of the use of PRF was presented in France, in 2001, by Choukroun et al. It is the successor of the platelet-rich plasma (PRP) with multiple benefits.
PRF consists of platelet, leukocyte cytokines, growth factors and fibrin network that interconnects them. Platelets produce platelet plug ie. blood clot and stimulate the secretion of growth factors. Growth factors govern proliferation, chemotaxis, synthesis of matrix and tissue morphogenesis. The release of cytokines and growth factors in PRF stimulates collagen synthesis and bone formation.
PRF occurs by only centrifuging patient's blood without the use of additional additives. It is applied in periodontal, oral, maxillofacial and plastic surgery and in otorhinolaryngology as an additional tool in the treatment of various forms of bone and mucosal defects, trauma and infections.
The biggest advantages of working with PRF are the ease of product preparation, low cost, availability to each patient and minimal trauma.

• Keywords: augmentacija alveolarne kosti; fibrin
• Keywords (english): alveolar ridge augmentation
• Language: croatian
• URN:NBN: urn:nbn:hr:127:568164
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-11-02 11:26:09