Excision and pathohistological diagnosis of atypical peripheral ossifying fibroma - Case report

master's thesis

• Title (croatian): Ekcizija i patohistološka dijagnostika atipičnog perifernog osificirajućeg fibroma - prikaz slučaja
• Author: Iva Burazin
• Mentor: Tomislav Katanec (mentor)
• Committee member: Tomislav Katanec (predsjednik povjerenstva)
• Committee member: Marko Granić (član povjerenstva)
• Committee member: Lana Bergman (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Department of Oral Surgery); Zagreb
• Defense date and country: 2024-03-07, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Oral Surgery

Abstract

Peripheral ossifying fibroma (POF) is a benign, reactive growth that appears on the gingiva, often triggered by local irritants such as dental plaque, tartar, or dental devices. This thesis aims to explore the clinical and histological features of POF, understand its etiology, and review various treatment options. A retrospective study was conducted on patients diagnosed with POF to collect data on demographics, lesion characteristics, and recurrence rates. The tissue composition of the lesions was analyzed through pathohistological examinations. A comparative context for the findings was also provided through a literature review. POF primarily impacts the anterior maxilla, and according to the research, there is a female predilection. Typically, the lesions exhibit a proliferation of fibroblastic cells, as well as areas of calcification and ossification. This is frequently accompanied by chronic inflammation and occasional ulceration. The high recurrence rate observed confirms the necessity of complete surgical excision and the removal of local irritants to reduce the risk of recurrence. Early detection and management of recurring lesions requires consistent follow up.

Abstract (croatian)

Periferni osificirajući fibrom (POF) je benigna, reaktivna izraslina koja se pojavljuje na gingivi, često izazvana lokalnim iritansima poput zubnog plaka, zubnog kamenca ili zubnih naprava. Ovaj rad ima za cilj istražiti kliničke i histološke značajke POF-a, razumjeti njegovu etiologiju i pregledati različite mogućnosti liječenja. Provedena je retrospektivna studija na pacijentima kojima je dijagnosticiran POF kako bise prikupili podaci o demografskim karakteristikama, karakteristikama lezija i stopama recidiva. Sastav tkiva lezija analiziran je histopatološkim pretragama. Usporedni kontekst za nalaze također je osiguran pregledom literature. POF primarno utječe na prednju maksilu, a prema istraživanjima, postoji ženska predispozicija. Tipično, lezije pokazuju proliferaciju fibroblastičnih stanica, kao i područja kalcifikacije i osifikacije. To je često popraćeno kroničnom upalom i povremenim ulceracijama. Uočena visoka stopa recidiva potvrđuje nužnost potpune kirurške ekscizije i uklanjanja lokalnih iritansa kako bi se smanjio rizik od recidiva. Rano otkrivanje i liječenje ponavljajućih lezija zahtijeva dosljedno praćenje.

• Keywords: Peripheral ossifying fibroma (POF); Dental Plaque; Dental Calculus; Dentures; Oral Surgical Procedures
• Keywords (croatian): Periferni osificirajući fibrom (POF); zubni plak; zubnin kamenac; zubne proteze; oralnokirurški postupci
• Language: english
• URN:NBN: urn:nbn:hr:127:615424
• Study programme: Title: Dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor dentalne medicine (doktor dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-06-29 10:12:27