Hijaluronska kiselina u dentalnoj medicini

master's thesis

• Title (english): Use of hyaluronic acid in dentistry
• Author: Petra Domislović
• Mentor: Ivana Šutej (mentor)
• Committee member: Ivana Šutej (predsjednik povjerenstva)
• Committee member: Krešimir Bašić (član povjerenstva)
• Committee member: Domagoj Vražić (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Chair of Pharmacology); Zagreb
• Defense date and country: 2021-07-08, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Hijaluronska kiselina linearni je polisaharid koji se nalazi u gotovo svim organima kralježnjaka. Najviša razina prisutna je u mekom vezivnom tkivu (pupkovina, sinovijalna tekućina, koža), a najniža u krvnom serumu. Prisutna je također i u tkivima oralne sluznice, osobito u nemineraliziranim tkivima kao što su gingiva i parodontni ligament. U mineraliziranim tkivima, kao što su cement i alveolarna kost, prisutne su niske količine. Većina stanica u tijelu ima sposobnost sinteze hijaluronske kiseline. Biokompatibilna je i neimunogena. Njeno djelovanje je protuupalno, bakteriostatsko i potiče cijeljenje. Primjena hijaluronske kiseline u terapijske svrhe u dentalnoj medicini počela je početkom 21. stoljeća. U terapiji parodontitisa primjenjuje se lokalno u kombinaciji s nekirurškom i kirurškom parodontnom terapijom te dovodi do značajnog kliničkog poboljšanja. Lokalnom
primjenom gela hijaluronske kiseline uočen je pozitivan učinak i kod pacijenata s gingivitisom. Inhibira patološki učinak dentalnog plaka na periimplantno tkivo i poboljšava cijeljenje mekog tkiva. Injekcije gela hijaluronske kiseline dovode do smanjenja „crnih trokuta“ čak i nakon jednokratne primjene, a bolji i dugotrajniji rezultati postižu se višestrukim injekcijama
hijaluronske kiseline u područje interdentalne papile. U terapiji temporomandibularnih poremećaja dovodi do poboljšanja funkcije
temporomandibularnog zgloba i ublažavanja boli, ali potrebna su daljnja istraživanja kako bi se dodatno istražila njezina primjena. Kod pacijenta s rekurentnim aftoznim ulceracijama dobra je alternativa kortikosteroidima jer dovodi do bržeg cijeljenja, ublažava bol te je sigurna za primjenu kod dojenčadi i trudnica. Kod pacijenata sa sindromom pekućih usta uočeno je ublažavanje simptoma.

Abstract (english)

Hyaluronic acid is a linear polysaccharide found in almost all vertebrate organs. The highest concentrations are found in soft connective tissues (umbilical cord, synovial fluid, skin) and the lowest in blood serum. Hyaluronic acid has been identified in all periodontal tissues, being particularly prominent in the non-mineralized tissues such as gingiva and periodontal ligament. Low quantities are to be found in mineralized tissues such as cementum and alveolar bone.
Most of the cells have the ability to synthesize hyaluronic acid. Hyaluronic acid is biocompatible and non-immunogenic. It has an anti-inflammatory and bacteriostatic properties, and promotes healing. It has been in use in dental medicine since the beginning of the 21st century. In the treatment of periodontitis, it is applied topically in combination with non-surgical and surgical periodontal therapy and leads to significant clinical improvement. Topical application of hyaluronic acid gel has been observed to have a positive effect in patients with gingivitis. It inhibits the pathological effect of dental plaque on peri-implant tissue and improves soft tissue healing. Hyaluronic acid gel injections lead to a reduction of ‘black triangles’ even after a single application, but better and longer-lasting results are achieved by multiple injections of hyaluronic acid into the area of the interdental papilla. In the treatment of temporomandibular disorders, it leads to improved temporomandibular joint function and pain relief, but more research is needed to further investigate its application. In patients with recurrent aphthous ulcers, it is a good alternative to corticosteroids because it leads to faster healing, relieves pain and is safe for use in infants and pregnant women. Relief of symptoms has been observed in patients with burning mouth syndrome.

• Keywords: hijaluronska kiselina; parodontne bolesti; poremećaji temporomandibularnog zgloba; sindrom pečenja usta
• Keywords (english): Hyaluronic Acid; Periodontal Diseases; Temporomandibular Joint Disorders; Burning Mouth Syndrome
• Language: croatian
• URN:NBN: urn:nbn:hr:127:449223
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-08-25 08:22:54