Učestalost i uzroci promjena u usnoj šupljini i sastavu sline u djece i adolescenata s poremećajima u jedenju

doctoral thesis

• Title (english): Frequency and causes of changes in the oral cavity and composition of saliva in children and adolescents with eating disorders
• Author: Tatjana Lesar
• Mentor: Sonja Kraljević-Šimunković (mentor)
• Committee member: Iva Alajbeg (predsjednik povjerenstva)
• Committee member: Vlaho Brailo (član povjerenstva)
• Committee member: Dubravka Negovetić Vranić (član povjerenstva)
• Committee member: Iva Mihatov Štefanović (član povjerenstva)
• Committee member: Nada Vrkić (član povjerenstva)
• Committee member: Nikola Petričević (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; Zagreb
• Defense date and country: 2021-05-19, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine
• Universal decimal classification (UDC): 616.31 - Stomatology

Abstract

Oboljeli od poremećaja u jedenju (PUJ) razvijaju brojne medicinske komplikacije koje
zahvaćaju sve organske sustave. Promjenama je zahvaćena i usna šupljina u kojoj se javlja
niz promjena, a prisutne su i promjene u volumenu i sastavu sline te u razinama
elektrolita. Cilj ovog rada bio je utvrditi razlike u učestalosti promjena u usnoj šupljini,
količini sline i koncentraciji ukupne amilaze i elektrolita u slini i serumu te utvrditi razlike
u stupnju uhranjenosti između pedijatrijskih bolesnika s poremećajima u jedenju i
kontrolne skupine. Ispitivalo se postoji li korelacija između pojavnosti promjena i stupnja
uhranjenosti. I konačno, utvrđivali su se glavni čimbenici koji utječu na pojavnost
promjena u usnoj šupljini u pedijatrijskih bolesnika s poremećajima u jedenju. U
istraživanje je bila uključena 101 ispitanica prosječne životne dobi 14,34 ± 1,99 godina,
od toga 50 ispitanica s poremećajem u jedenju i 51 ispitanica kontrolne skupine.
Bolesnice s PUJ-om bile su značajno slabije uhranjene i imale su učestalije, izraženije i
brojnije promjene u usnoj šupljini nego ispitanice kontrolne skupine. U bolesnica s PUJom utvrđena je viša koncentraciju anorganskih fosfata u slini te više koncentracije
magnezija, albumina, feritina i vitamin B12 u serumu. Ostali ispitavani parametri nisu su
se značajno razlikovali među ispitivanim skupinama. Istraživanje je pokazalo da postoji
povezanost između promjena u usnoj šupljini, životne dobi, trajanja poremećaja i stupnja
uhranjenosti te koncentracija nekih od ispitivanih parametara u slini i serumu.
Prepoznavanje oralnih promjena od strane stomatologa te rano upućivanje na liječenje
zasigurno bi doprinjelo sprječavanju daljnjih komplikacija uzrokovanih bolešću.

Abstract (english)

Numerous changes involving all organ systems are developing as a result of dysfunctional
eating behavior in patients with eating disorders (ED). The changes also affect the oral
cavity, in which a number of changes occur, and there are also changes in the volume and
composition of saliva and in electrolyte levels. The aim of this study was to determine the
differences in the frequency of changes in the oral cavity, the amount of saliva and the
concentration of total amylase and electrolytes in saliva and serum, and to determine
differences in nutritional status between pediatric patients with eating disorders and
control groups. It was examined whether there was a correlation between the occurrence
of changes and the degree of nutrition. And finally, the main factors influencing the
occurrence of changes in the oral cavity in pediatric patients with eating disorders were
identified. The study included 101 subjects with a mean age of 14.34 ± 1.99 years, of
which 50 subjects with eating disorders and 51 subjects in the control group. Patients with
PUJ were significantly malnourished and had more frequent, more pronounced and
numerous changes in the oral cavity than the subjects of the control group. Higher serum
concentrations of inorganic phosphates and serum magnesium, albumin, ferritin and
vitamin B12 were found in patients with PUJ. Other examined parameters did not differ
significantly between the examined groups. The study showed that there was an
association between the changes in the oral cavity, age, duration of the disorder and the
degree of nutrition, and the concentration of some of the examined parameters in saliva
and serum. Recognition of oral changes by the dentist and early referral for treatment
would certainly help to prevent further complications caused by the disease.

• Keywords: poremećaji hranjenja i prehrane; usta; slina; dijete; adolescent; stupanj uhranjenosti
• Keywords (english): Feeding and eating disorders; mouth; saliva; child; adolescent; nutritional status
• Language: croatian
• URN:NBN: urn:nbn:hr:127:768779
• Promotion: 2021
• Study programme: Title: dental medicine; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo, polje dentalna medicina (doktor/doktorica znanosti, područje biomedicine i zdravstvo, polje dentalna medicina)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-06-24 12:07:17