Ima li hijaluronska kiselina ulogu kod augmentacije kosti?

master's thesis

• Title (english): Is there a role for hyaluronic acid in bone regeneration?
• Author: Lucija Herceg
• Mentor: Darko Božić (mentor)
• Committee member: Darko Božić (predsjednik povjerenstva)
• Committee member: Ana Badovinac (član povjerenstva)
• Committee member: Ivan Puhar (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Department of Periodontology); Zagreb
• Defense date and country: 2020-09-23, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine

Abstract

Sve češća upotreba dentalnih implantata u oralnim rehabilitacijama, čini zahvate augmentacije
kosti nužnima i učestalijima u svakodnevnoj praksi. Augmentacija kosti kirurški je zahvat
nadogradnje kosti koji se izvodi kada trenutačna koštana masa nije dostatna za implantološku
terapiju. Nadogradnja koštane strukture može biti izvedena različitim metodama koje
upotrebljavaju faktore rasta, faktore diferencijacije te koštane nadomjesne materijale (autogeni
transplantat, alogeni transplantat, ksenotransplantat, aloplastični materijali). Iako je autologna
kost i dalje „zlatni standard” u regenerativnoj kirurgiji, istraživači, desetljećima, pokušavaju
pronaći nadomjesni materijal koji bi, u terapijskim učincima, nadmašio autolognu kost.
Napretkom novih tehnologija dolazi do razvoja biomaterijala, koji mogu poboljšati koštanu
augmentaciju ako se koriste u kombinaciji s nadomjesnim materijalima ili bioaktivnim
komponentama. Hijaluronska kiselina, kao takav biomaterijal, sveprisutna je u regenerativnim
zahvatima zbog svoje biokompatibilnosti, netoksičnosti i biorazgradivosti. Ona je biomolekula
široko rasprostranjena u ljudskom organizmu te ključna komponenta ekstracelularnog
matriksa. Iako brojne studije potvrđuju njezin obećavajući učinak u koštanim augmentativnim
zahvatima, to područje zahtijeva dodatna istraživanja u budućnosti. Svrha ovoga diplomskoga
rada jest opisati biološke osnove hijaluronske kiseline i objasniti njezinu ulogu u augmentaciji
kosti.

Abstract (english)

The increasing use of dental implants in oral rehabilitation makes bone augmentation
procedures necessary and more frequent in everyday practice. Bone augmentation is a
procedure which is performed when the current bone mass of the jaw is not sufficient to
successfully incorporate dental implants. The augmentation of the bone volume is performed
using different methods, including the use of growth factors, differentiation factors and bone
grafts or substitutes (autograft, allograft, xenograft and alloplasts). Although autologous bone
graft is still the “gold standard” in regenerative surgery, researchers have been attempting for
decades to find a bone substitute material which can be used instead of autologous bone grafts
and which would have a better therapeutic effect. The advances in emerging technologies lead
to the development of biomaterials, which can enhance bone augmentation procedure when
they are used in combination with replacement materials or bioactive components. Hyaluronic
acid, as such a biomaterial, is ubiquitous in regenerative procedures due to its biocompatibility,
nontoxicity, and biodegradability. It is a biomolecule widely distributed in the human body and
a critical component of the extracellular matrix. Although numerous studies have confirmed its
promising effect in bone augmentation procedures, this area requires further research in the
future. The purpose of this thesis is to define the biological basis of hyaluronic acid and to
explain its role in bone augmentation.

• Keywords: augmentacija alveolarne kosti; hijaluronska kiselina; ekstracelularni matriks
• Keywords (english): Alveolar Ridge Augmentation; Hyaluronic Acid; Extracellular Matrix
• Language: croatian
• URN:NBN: urn:nbn:hr:127:097785
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-01-21 12:17:46