Utjecaj sline i zubne paste na stvaranje alkalno topljivih fluorida na površini cakline

master's thesis

• Title (english): The effect of fluoride toothpaste and saliva combination on formation of alkali - soluble fluorides on enamel surface
• Author: Margareta Ognjanović
• Mentor: Kristina Peroš (mentor)
• Committee member: Kristina Peroš (predsjednik povjerenstva)
• Committee member: Ivana Šutej (član povjerenstva)
• Committee member: Ana Andabak Rogulj (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Chair of Pharmacology); Zagreb
• Defense date and country: 2020-09-25, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine

Abstract

Fluoridirana zubna pasta, zbog svoje učinkovitosti i lake primjene, danas je daleko najčešći oblik kontrole karijesa diljem svijeta. U borbi protiv karijesa fluoridi u zubnim pastama predstavljaju snažno terapijsko sredstvo. Primjenom fluoridiranih zubnih pasti dolazi do odlaganja alkalno topljivih fluorida u obliku globula sličnih kalcijevom fluoridu. Kalcijev fluorid smatra se najvažnijim produktom koji nastaje na caklini nakon topikalno primijenjenih fluoridiranih preparata. Svrha ovog rada jest prikazati učinak različitih fluoridiranih pasti za zube na odlaganje alkalno topljivih fluorida na površinu cakline, uzimajući u obzir i njihovu interakciju sa slinom pušača i slinom nepušača. S obzirom na to da zubne paste sličnih koncentracija sadržavaju različite spojeve fluora koji imaju različitu sposobnost otpuštanja iona fluora u oralnom okruženju, smatra se da bi te razlike u topljivosti različitih spojeva fluorida mogle utjecati na količinu kalcijeva fluorida stvorenog na površini cakline. Zahvaljujući organskom nosaču fluora, aminofluoridne zubne paste pokazale su se učinkovitijima u remineralizaciji karijesne lezije u usporedbi sa zubnim pastama koje sadržavaju spojeve s monofluorofosfatom i anorganske spojeve fluora. Ustanovljeno je da aminofluoridni preparati ostvaruju veću koncentraciju fluora u slini u odnosu na natrij fluoridne. Također, pokazalo se da je stvaranje alkalno topljivih fluorida primjenom aminofluoridne zube paste izraženije uz slinu pušača dok djelovanje natrij fluoridne zubne paste nije vezano za slinu.

Abstract (english)

Due to their effectiveness and easy application, fluoride toothpastes are by far the most common form of caries control worldwide. In the fight against caries, fluorides in toothpastes are a powerful therapeutic agent. The use of fluoride toothpastes results in the deposition of alkalisoluble fluorides in the form of calcium fluoride-like globules. It is considered that calcium fluoride is the most important product formed on enamel after fluoride preparations are topically applied. The purpose of this paper is to show the effectiveness of different fluoride toothpastes on the deposition of alkali-soluble fluorides on the enamel surface, with respect to their interaction with the saliva of smokers and the saliva of non-smokers. As toothpastes of similar concentrations contain different fluoride compounds which have different abilities to release fluoride ions into the oral environment, it is considered that these differences in the solubility of different fluoride compounds could affect the amount of calcium fluoride formed on the enamel surface. Due to the organic fluoride carrier contained in them, amine fluoride toothpastes have shown to be more effective in remineralizing carious lesions when compared to toothpastes that contain monofluorophosphate and inorganic fluoride compounds. It was found that amine fluoride preparations achieve higher concentrations of fluoride in saliva when compared to sodium fluoride ones. Additionally, the formation of alkali-soluble fluorides has been demonstrated to be more efficient when using the amine fluoride toothpaste combined with the smokers’ saliva, and the effect of sodium fluoride toothpaste is not related to saliva at all.

• Keywords: dentalna fluoroza; zubne paste; slina; zubna caklina
• Keywords (english): Dental Fluorosis; Toothpastes; Saliva; Dental Enamel
• Language: croatian
• URN:NBN: urn:nbn:hr:127:826945
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-11-24 10:36:30