Propisivanje lijekova u dentalnoj medicini u Republici Hrvatskoj

master's thesis

• Title (english): DRUG PRESCRIBING IN DENTAL MEDICINE IN THE REPUBLIC OF CROATIA
• Author: Katja Pernarić
• Mentor: Ivana Šutej (mentor)
• Committee member: Ivana Šutej (predsjednik povjerenstva)
• Committee member: Kristina Peroš (član povjerenstva)
• Committee member: Božana Lončar Brzak (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Chair of Pharmacology); Zagreb
• Defense date and country: 2019-09-27, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine

Abstract

U stomatološkoj praksi propisivanje je lijekova učestalo s obzirom na česte upale, zubobolje i ostala stanja koja zahtijevaju uporabu lijekova, uz stomatološki tretman. Najčešće propisivani lijekovi u stomatološkim ordinacijama, uz antibakterijske lijekove, jesu antimikotici, analgetici, protuupalni lijekovi, benzodiazepini te topikalni kortikosteroidi. Neracionalna i nezasnovana uporaba lijeka može dovesti do mnogih komplikacija, na sistemskoj i lokalnoj razini, poput razvoja rezistencije na lijek ili interakcije s drugim lijekovima.
Svrha ovog istraživanja bila je statistički prikazati potrošnju lijekova koje su propisali doktori dentalne medicine (DDM) u Republici Hrvatskoj u razdoblju od 2014. do 2017. godine. Podatci su dobiveni na temelju izvješća o potrošnji lijekova zaprimljenih od HZZO-a. Najčešće propisivani lijekovi prema rezultatima jesu antibiotici. Penicilinska skupina antimikrobnih lijekova najčešći je izbor u liječenju, posebno amoksicilin s klavulanskom kiselinom, a potom skupina linkozamida (klindamicin) te cefalosporini i metronidazol. Antibiotici širokog spektra češće su korišteni od onih uskog spektra. Ostali učestalo propisivani lijekovi jesu nesteroidni protuupalni analgetici, poput ibuprofena. Također, uočen je porast u propisivanju kortikosteroida na lokalnoj i na sistemskoj razini te porast u upotrebi antigljivičnih lijekova. Analizirajući rezultate istraživanja, može se zaključiti da je u razdoblju od 2014. do 2017. godine primijećen trend povećanja potrošnje pojedinih skupina lijekova koje su propisali DDM. Najveći porast zabilježen je u skupini antibakterijskih lijekova i lijekova s protuupalnim učinkom. Na temelju dobivenih rezultata istraživanja uočena je potreba za dodatnom edukacijom stomatologa i pacijenata kako bi racionalno i kritički donijeli odluku o potrebi za propisivanjem lijekova.

Abstract (english)

The use of medications in dental clinical practice is common, due to frequent odontogenic infections, toothache and many other conditions that require medical treatment. The most frequently used medications are antibiotics, followed by antifungals, analgesics, anti-inflammatory drugs, benzodiazepine and topical corticosteroids. Uncritical and inappropriate use of any drug may result in multiple complications at a local and/or systemic level, such as drug resistance or drug interactions.
The objective of this study was to show the use of the drugs prescribed by dental practitioners in the Republic of Croatia in the period from 2014 to 2017.
Data presented in this study were obtained from the reports on the use of prescribed drugs available in the Croatian Health Insurance Institute, the national insurance company.
The results demonstrated that antibiotics were the most frequently prescribed drugs by dentists. Penicillin was the most commonly prescribed class of antibiotics, especially amoxicillin with clavulanic acid. Lincosamides were also broadly used antibiotics in dental medicine, especially clindamycin, followed by cephalosporines and metronidazole. Broad-spectrum antibiotics have been used more frequently than narrow-spectrum ones, which ultimately leads to the increasing bacterial resistance to antibiotics. Other most commonly prescribed drugs were anti-infammatory drugs, especially the non-steroidal anti-inflammatory drug, ibuprofen. The results also showed a small increase in prescribing corticosteroids, both for local and systemic use, as well as the increase in antifungals and antiviral medical treatments.
The results of the study indicate that there was an increase in consuming the drugs prescribed by dentists in the period from 2014 to 2017. Antibiotics and anti-inflammatory drugs were the most frequently prescribed medications. These findings also suggest that there is a need to provide additional education on rational use of drugs in dental practice.

• Keywords: propisivanje lijekova; potrošnja lijekova; doktori dentalne medicine; antibiotici
• Keywords (english): drugs; dental practitioners; antibiotics; resistance
• Language: croatian
• URN:NBN: urn:nbn:hr:127:205494
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2019-11-20 11:57:47