Migrena i moždani udar

master's thesis

• Title (english): Migraine and stroke
• Author: Dunja Plavšić
• Mentor: Arijana Lovrenčić-Huzjan (mentor)
• Committee member: Arijana Lovrenčić-Huzjan (predsjednik povjerenstva)
• Committee member: Vanja Bašić Kes (član povjerenstva)
• Committee member: Ivan Puhar (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Chair of Neurology); Zagreb
• Defense date and country: 2018-09-26, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine

Abstract

Migrena je primarna glavobolja karakterizirana ponavljajućim napadajima pulsirajuće glavobolje praćene mučninom, povraćanjem i katkad raznim kombinacijama drugih neuroloških simptoma. Migrena je treća najučestalija bolest u svijetu s prevalencijom od 14.7%. Smatra se da migrenu uzrokuje neuronalna disfunkcija. Najčešći su oblici migrene su oblici migrene migrena bez aure i s aurom. Migrena se češće pojavljuje u žena nego muškaraca, što se može objasniti djelovanjem hormona.
Moždani udar neurološki je poremećaj kod kojeg dolazi do odumiranja moždanog tkiva zbog prekida krvotoka i nedostatne opskrbe mozga kisikom u onim dijelovima što opskrbljuje oštećena krvna žila. Moždani u i vodeći je je uzrok smrtnosti i invalidnosti u svijetu. Postoje dvije vrste moždanog udara: ishemijski moždani udar i hemoragijski udar.
Povećani rizik od ishemijskog i hemoragijskog moždanog udara često se povezuje s osobama koje boluju od migrene. Poveznica je najizraženija u žena mlađih od 45 godina s čestim napadajima. Žene koje imaju migrenu, a puše i koriste oralna kontracepcijska sredstva, u većem su riziku od moždanog udara. Različite teorije objašnjavaju povećani rizik nastanka moždanog udara u osoba s migrenom. Spominju se tri moguća objašnjenja.
Prvo je da sama patofiziološka podloga migrene može dovesti do moždanog udara. Drugo je da postoje zajedničke komorbiditetne bolesti kod migrene i moždanog udara i treće je da se neki sindromi mogu manifestirati glavoboljom sličnoj migreni i cerebrovaskularnim bolestima. Također, lijekovi protiv migrene, osobito vazokonstriktori, mogu biti povezani s povećanim rizikom od moždanog udara.

Abstract (english)

A migraine is a primary headache characterized by recurrent attacks of pulsating headache accompanied by nausea, vomiting and other combinations of neurogical symptoms. Migraine is the third most frequent disease in the world with prevalence of 14.7 %. It is generally thought that the migraine is caused by neuronal dysfunction. The most common types of migraine are without aura and with aura.
The migraine affects women more than men, which is explained by the sex hormones activity.
A stroke is a neurological disorder in which poor blood flow to the brain and insufficient oxygen level result in cell death. Stroke is the leading cause of death and disability in the world. There are two types of stroke: ischemic stroke and hemorrhagic stroke.

People with migraine are often associated a higher risk of ischemic and haemorrhagic
People with migraine are often associated a higher risk of ischemic and haemorrhagic stroke. The association is the most noticeable in women under age of 45 with frequent migraine attacks. Women who suffer from migraine and smoke or use oral contraceptives are at the higher risk of stroke. Various theories explain stroke in patients with at the higher risk of stroke in patients with migraine. There are three possible explanations mentioned. One is that the pathophysiological background of migraine itself can lead to stroke. The second is that there are common comorbidities in migraine and stroke, the third is that some syndromes can manifest a comorbidities in migraine and stroke, the third is that some syndromes can manifest in a headache similar to migraine and cerebrovascular diseases. Also, the migraine medications, Also, the migraine medications, especially vasoconstrictors, could be linked with a higher stroke risk.

• Keywords: Migrena; glavobolja; aura; ishemijski moždani udar; hemoragijski moždani udar
• Keywords (english): migraine; headache; aura; ischemic stroke; hemorrhagic stroke
• Language: croatian
• URN:NBN: urn:nbn:hr:127:640691
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2019-01-11 12:36:31