Medikamentozna osteonekroza čeljusti

master's thesis

• Title (english): Medication related osteonecrosis of the jaw
• Author: Vlatko Reschner
• Mentor: Davor Brajdić (mentor)
• Committee member: Davor Brajdić (predsjednik povjerenstva)
• Committee member: Josip Biočić (član povjerenstva)
• Committee member: Ivan Zajc (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Department of Oral Surgery); Zagreb
• Defense date and country: 2018-03-23, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Oral Surgery

Abstract

Medikamentozna osteonekroza čeljusti, je bolest, koja nastaje upotrebom dviju vrsta lijekova: antiangiogenih lijekova te antiresorptivnih lijekova. Najpoznatiji uzročnik medikamentozne osteonekroze te lijekovi pri kojima je prvi puta otkrivena medikamentoza osteonekroza su bifosfonati koji spadaju u skupinu antiresorptivnih lijekova. Sam mehanizam nastanka medikamentozne osteonekroze nije do današnjega dana razjašnjen, ali postoje različite teorije njezinog nastanka. Postoje također različiti čimbenici, o kojima ovisi incidencija osteonekroze, kao što su način primjene lijeka, trajanje terapije, doziranje specifičnog lijeka, potentnost samoga lijeka, njegova akumulacija u tijelu te incidencija koja je ovisna o lokalnim, anatomskim te sistemskim faktorima. Medikamentoznu osteonekrozu klinički dijelimo na 4 različita stadija, s obzirom na količinu eksponirane kosti te upalu okolnoga tkiva. Stadije klasificiramo od brojke 0 do broja 3. Medikamentoznu osteonekrozu liječimo različito u različitim stadijima. Kako dijelimo osteonekrozu na četiri stadija, tako je i pristup terapiji u svakom stadiju osteonekroze različit. Prevenciju nastanka medikamentozne osteonekroze također dijelimo na preventivu koju
provodimo prije početka terapije lijekovima i na preventivu koju provodimo nakon terapije
lijekovima ili za vrijeme terapije.

Abstract (english)

Medication-related osteonecrosis of the jaw is a disease that occurs with the use of two types of medication; antiangiogenic drugs and antiresorptive drugs. The most known cause of medication related osteonecrosis as well as medication which has been the first to detect
medication-related osteonecrosis are bisphosphonates, which belong to the group of antiresorptive drugs.
The mechanism for the development of medication-related osteonecrosis, is still not clarified to this day, although different theories exist explaining the development. There are also various factors that depend on the incidence of osteonecrosis, such as the mode of administration of the drug, duration of therapy, specific drug dosage, potency of the drug itself, its accumulation in the body, also incidence dependent on local, anatomic and systemic factors. Medication-related osteonecrosis is divided into 4 different stages, considering the amount of exposed bone and inflammation of the surrounding tissue. Stages are classified from 0 to 3. Medication related osteonecrosis is treated differently at different stages. Since osteonecrosis is separated into four stages, therapy at each stage of osteonecrosis is specific to the stage which has been diagnosed.
Prevention of medication-related osteonecrosis is separated into two preventative measures. First line of prevention is before drug therapy begins and secondly as well as after therapy with drugs or during treatment.

• Keywords: Medikamentozna osteonekroza čeljusti; bifosfonati; lijekovi; terapija
• Keywords (english): Medication related osteonecrosis of the jaw; bisphosphonates; drugs; therapy
• Language: croatian
• URN:NBN: urn:nbn:hr:127:125980
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-11-22 09:20:01