Terapijske mogućnosti u liječenju oralnog lihena planusa

master's thesis

• Title (english): Therapeutic options for the treatment of oral lichen planus
• Author: Ema Vindiš
• Mentor: Ana Andabak Rogulj (mentor)
• Committee member: Ana Andabak Rogulj (predsjednik povjerenstva)
• Committee member: Božana Lončar Brzak (član povjerenstva)
• Committee member: Jelena Dumančić (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Department of Oral Medicine); Zagreb
• Defense date and country: 2018-07-11, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Oral Medicine

Abstract

Oralni lihen planus (OLP) je kronična upalna bolest sluznice usne šupljine nepoznate etiologije. Najčešće je zahvaćena obrazna sluznica obostrano, i nešto rjeđe jezik, gingiva, nepce, usnice i dno usne šupljine. Promjene OLP-a variraju u kliničkoj slici od retikularnog oblika koji je u najvećem broju slučajeva asimptomatski, do atrofično-erozivnog oblika kojeg prate simptomi pečenja i boli te otežano uzimanje hrane. S obzirom na činjenicu da je OLP
bolest nepoznate etiologije, liječenje je simptomatsko i podrazumijeva suzbijanje znakova i simptoma bolesti te se u tu svrhu koriste razni topikalni i sustavni lijekovi. Kao prva linija terapije u liječenju simptomatskog OLP-a koriste se topikalni kortikosteroidi, dok se za liječenje tvrdokornih lezija koje ne odgovaraju na lokalno liječenje koriste sistemski kortikosteroidi. Međutim, nedostatak uvjerljivih dokaza o učinkovitosti dosadašnjih terapija, uključujući i topikalne kortikosteroide, i brojne nuspojave koje se javljaju, u posljednjih
nekoliko godina, rezultiralo je pojavljivanjem i razvojem novih terapija. Samo neke od spomenutih terapija su takrolimus, efalizumab, dapson, interferon, retinoična kiselina, fotokemoterapija psoralenom i ultraljubičastim A zrakama (PUVA), aloe vera, antimalarici, antibiotici i mnogi drugi. Navedene terapije samo dijelom zadovoljavaju svojstva djelotvornosti i sigurnosti primjene, što opravdava kontinuirano traženje i ispitivanje novih metoda liječenja.

Abstract (english)

Oral lichen planus (OLP) is a chronic inflammatory disease of the mucose membrane of the mouth of an unknown etiology. The most commonly affected part is buccal mucosa bilaterally, less commonly tongue, gingiva, palate, lips and the bottom of oral cavity. Changes in OLPs vary in clinical features from reticular form that is in most cases asymptomatic, to atrophic-erosive one, accompanied by symptoms of burns and pain followed by difficulties in food intake. Given the fact that the OLP is a disease of unknown etiology, the treatment is symptomatic and involves suppression of signs and symptoms of the disease using various topical and systemic drugs for that purpose. The first line of therapy for the treatment of symptomatic OLPs are topical corticosteroids, while systemic corticosteroids are used for the treatment of persisting lesions that do not respond to local treatment. However, lack of convincing evidence of the efficacy of previous therapies, including topical corticosteroids, and numerous side effects that have occurred over recent years have resulted in the emergence and development of new therapies. Only some of the therapies mentioned are tacrolimus, efalizumab, dapson, interferon, retinoic acid, photochemotherapy with psoralen and ultraviolet A rays (PUVA), aloe vera, antimalarials, antibiotics and many others. These therapies only partially meet the properties of efficacy and safety of use, justifying the
continuous search and testing of new treatment methods.

• Keywords: oralni lihen planus; kortikosteroidi; liječenje; nuspojave
• Keywords (english): oral lichen planus; corticosteroids; therapy; side effects
• Language: croatian
• URN:NBN: urn:nbn:hr:127:212213
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-11-22 09:02:36