Matične stanice iz mliječnih zuba: postupak pohrane i upotreba

master's thesis

• Title (english): Stem Cells from Human Exfoliated Deciduous Teeth: Banking Procedure and Usage
• Author: Lucija Lomnicki
• Mentor: Dubravka Negovetić-Vranić (mentor)
• Committee member: Dubravka Negovetić-Vranić (predsjednik povjerenstva)
• Committee member: Hrvoje Jurić (član povjerenstva)
• Committee member: Silvana Jukić Krmek (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Department of Paediatric and Preventive Dentistry); Zagreb
• Defense date and country: 2017-09-25, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Children's and Preventive Dental Medicine

Abstract

Istraživanjem matičnih stanica došlo je do novih spoznaja o mogućnosti liječenja stanicama koje se razlikuju od kirurške terapije i terapije lijekovima. SHED su matične stanice pronađene u tkivu mliječnih zuba kod djece. SHED su nezrele, nespecijalizirane stanice iz mliječnih zuba koje mogu rasti u specijalizirane vrste stanica pomoću postupka poznatog kao diferencijacija. SHED stanice se brzo razmnožavaju i rastu mnogo brže od odraslih matičnih stanica, sugerirajući da su manje zrele pa imaju potencijal razviti više vrsta tkiva nego druge vrste matičnih stanica. Vrste SHED-a su: adipociti, hondrociti, osteoblasti i mezenhimalne matične stanice.
Znanstvenici su dosadašnjim istraživanjima dokazali da se SHED mogu upotrebljavati za regeneraciju zubnih struktura i kosti, u terapiji tkiva neurodegenerativnih stanja kod Parkinsonove bolesti i multiple skleroze, bolesti jetre, dijabetesa, kardiovaskularnih bolesti, autoimunih bolesti, poremećaja mišićno-koštanog sustava i živaca, regeneracija tkiva nakon ozljeda mozga ili leđne moždine. Povećanjem broja ljudi pogođenih degenerativnim bolestima, bit će sve više potrebe za novim mogućnostima liječenja zbog stalnog starenja populacije. Pohranjivanje SHED-a osigurat će njihovu dostupnost u budućnosti, onda kada to ljudima bude najviše potrebno. SHED će imati najveći budući učinak ako se pohrane dok su pacijenti mladi i zdravi.

Abstract (english)

Stem cell research has led to new insights about the possibilities of cell therapy, which differ from surgical therapy and drug therapy. SHED are stem cells found in the exfoliated deciduous teeth of children. SHED cells are immature, unspecialized cells in the deciduous teeth that are able to grow into specialized cell types by a process known as differentiation. SHED cells multiply rapidly and grow much faster than adult stem cells, suggesting that they are less mature and they have the potential to develop into a wider variety of tissue types. Types of SHED are adipocytes, chondrocytes, osteoblasts and mesenchymal stem cells.
Scientists have proved by recent studies that SHED can be used for regeneration of dental tissues and bones, in the treatment of neurodegenerative disorders such as Parkinson's disease and multiple sclerosis, liver disorders, diabetes, cardio-vascular diseases, autoimmune diseases, disorders of musculoskeletal system and neurological system, regeneration of tissue following brain and spinal cord injuries. As the number of people affected by degenerative diseases increases and well as due to overall aging of population the necessity for new therapeutical possibilities will grow. Banking of SHED shall ensure their availability in the future when they shall be most needed. Banking of SHED shall be the most efficient if they are banked while patients are young and healthy.

• Keywords: matične stanice; SHED; vrste SHED-a; upotreba; pohrana
• Keywords (english): stem cells; SHED; types of SHED; usage; banking
• Language: croatian
• URN:NBN: urn:nbn:hr:127:968792
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-01-18 09:36:46