Remineralizacija tvrdih zubnih tkiva

master's thesis

• Title (english): Remineralization of Hard Dental Tissues
• Author: Blanka Knežević
• Mentor: Katica Prskalo (mentor)
• Committee member: Katica Prskalo (predsjednik povjerenstva)
• Committee member: Nada Galić (član povjerenstva)
• Committee member: Sanja Šegović (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Department of Endodontics and Restorative Dentistry); Zagreb
• Defense date and country: 2017-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Endodonics and Restorative Dentistry

Abstract

Unatoč velikim ulaganjima u istraživanja i napretku u terapijskom pristupu posljednjih desetljeća, noviji epidemiološki podaci upućuju da je karijes još uvijek velik javnozdravstveni problem u mnogim zemljama u razvoju. Karijesni proces kontinuum je izmjena brojnih ciklusa demineralizacije i remineralizacije. Početno nastaje površinska djelomično demineralizirana lezija. Terapijom remineralizacijskim postupcima u fazi nekavitirane lezije moguće je postići restituciju karijesne lezije ponovnom ugradnjom minerala. Progresijom karijesnog procesa, naposlijetku nastaje kavitacija.
Ključno je, dakle, terapiji karijesa pristupati rano, djelovati preventivno i interceptivno.
Remineralizacija je proces obnove demineralizacijom oštećenih kristala hidroksilapatita. Iako je o njoj dugo sve poznato, tek je posljednjih desetljeća prihvaćena njezina terapijska važnost. Podrazumijeva proces obnove karijesom oštećene cakline i dentina novim mineralnim materijalom prirodno (spontano) ili potaknuto vanjskim djelovanjem, različitim preparatima. Velik značaj pri tome imaju fluoridi i zato su usko vezani uz pojam remineralizacije.
Brojni su preparati na bazi fluorida i drugih minerala koji se koriste pri remineralizacijskim postupcima. Bitna su i druga sredstva, primjerice antimikrobni preparati, umjetni zaslađivači i postupci koji stvaraju uvjete za odvijanje remineralizacije.
Uz sve metode fluoridacije, uporaba restaurativnih materijala koji otpuštaju fluoridne ione za trajne restauracije način je da se omogući potrebna izloženost fluoridima. Fluoridi otpušteni iz restaurativnih materijala djeluju na karijesnu leziju tako da smanjuju i sprječavaju demineralizaciju i potiču remineralizaciju tvrdih zubnih tkiva. Omogućuju remineralizaciju podležećeg dentina i sprječavaju nastanak sekundarnog karijesa.

Abstract (english)

Despite the great efforts made in research of dental caries etiology and improvements in treatment approaches in the last decades, recent epidemiological data reveal that caries is still a great public health problem. The process of caries is a continuum resulting from many cycles of demineralization and remineralization. At first, the result is subsurface lesion with evident mineral loss. In the phase of non-cavitated lesion, through different remineralization approaches, it is possible to achieve restitution of the caries by rebuilding new mineral material. The progression of process ends with cavitation.
Thus, it is essential to approach caries therapy early and to act preventively and interceptively.
Remineralization is a natural process of restoration of initial caries lesion. Its therapeutic importance has only been accepted in the recent decades. It implies a process of restoring the enamel damaged by caries with new mineral material either naturally (spontaneously) or externally. In so doing, flourides are of great importance and are closely related to the term remineralization.
There are numerous fluoride and other mineral based vehicles used for remineralization. Vehicles such as antimicrobial agents and artificial sweeteners, as well as procedures that create conditions for remineralization are also important.
The use of fluoride-releasing dental restorative materials for permanent restorations is a way to allow the necessary exposure to flouride. Fluorides from dental restorative materials affect caries lesion so as to reduce and prevent demineralization and promote the remineralization of hard tissues. They allow remineralization of dentine beneath restauration and prevent the formation of secondary caries.

• Keywords: remineralizacija; fluoridacija; kazeinfosfopeptid; restaurativni materijali; staklenoionomerni cementi
• Keywords (english): remineralization; fluoridation; casein phosphopeptide; fluoride-releasing materials; glass-ionomer cements
• Language: croatian
• URN:NBN: urn:nbn:hr:127:617679
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-08-30 09:53:53