Očuvanje oralnog zdravlja u pacijenata liječenih transplantacijom matičnih stanica

master's thesis

• Title (english): Maintaining oral health in patients treated with hematopoietic stem cell transplantation
• Author: Mateja Prskalo
• Mentor: Vlaho Brailo (mentor)
• Committee member: Vlaho Brailo
• Committee member: Marinka Mravak-Stipetić
• Committee member: Bernard Janković
• Granter: University of Zagreb; School of Dental Medicine; (Department of Oral Medicine); Zagreb
• Defense date and country: 2015-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Oral Medicine

Abstract

TKMS je standardni postupak u liječenju pacijenata oboljelih od hematoloških malignih bolesti i praćena je brojnim oralnim komplikacijama od kojih su najznačajnije mukozitis, kserostomija i GvHD. Usna šupljina predstavlja značajan izvor mikroorganizama koji u imunosuprimiranih pacijenata mogu izazvati i sistemsku infekciji (septikemiju). Zbog toga je održavanje oralnog zdravlja kod pacijenata koji se liječe TKMS od presudne važnosti za prevenciju i smanjenje kako oralnih, tako i sustavnih komplikacija. Stomatološko liječenje provodi se prije, tijekom i nakon TKMS. Cilj stomatološkog liječenja prije TKMS je eliminirati sve moguće infekcije iz usne šupljine i pristupiti TKMS s potpuno saniranom usnom šupljinom. Za vrijeme TKMS cilj stomatološkog liječenja je svesti broj oralnih mikroorganizama na minimum, čime se smanjuje rizik za sistemsku infekciju i djeluje na incidenciju i kliničku sliku mukozitisa. Poslije TKMS potrebno je nastaviti s održavanjem oralne higijene, a kod pacijenata koji su razvili kronični GvHD provoditi redovite kontrole u svrhu što ranijeg otkrivanja oralnog karcinoma.

Abstract (english)

Hematopoietic stem cell transplantation (HSCT) is a standard procedure for the treatment of patients suffering from hematological malignancies. It is often followed by numerous oral complications like mucositis, xerostomia and graft versus host disease (GvHD). The oral cavity represents an important source of microorganisms in immunosuppressed patients, which can cause systemic infections (septicemia). Maintaining oral health in patients that are treated with HSCT is of utmost importance for preventing both oral and the aforementioned systemic complications.
Dental treatment is performed before, during and after HSCT. The goal of a dental treatment before HSCT is to eliminate all possible infections of the oral cavity and approach HSCT with a remediated oral cavity. Dental treatment during HSCT is focused on keeping the number of microorganisms in the oral cavity to a minimum, which leads to lower risks for systemic infections and also has an effect on the incidence and clinical manifestation of mucositis. After the HSCT meticulous oral hygiene must be maintained, while patients who developed chronic oral GvHD need to be regularly monitored because of early detection of oral cancer.

• Keywords: oralna medicina; oralno zdravlje; transplantacija krvotvornih matičnih stanica
• Keywords (english): oral medicine; oral health; Hematopoetic Stem Cell Transplantation
• Language: croatian
• URN:NBN: urn:nbn:hr:127:213438
• Study programme: Title: Dental Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2015-10-30 11:37:06