prikaz prve stranice dokumenta The Association between Resistance and Virulence of Klebsiella pneumoniae in High-Risk Clonal Lineages ST86 and ST101
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Scientific paper - Original scientific paper
The Association between Resistance and Virulence of Klebsiella pneumoniae in High-Risk Clonal Lineages ST86 and ST101
Microorganisms, 12 (2024), 10; 1997. https://doi.org/10.3390/microorganisms12101997
Pristas, Irina; Ujevic, Josip; Bodulić, Kristian; Andrijasevic, Natasa; Bedenic, Branka; Payerl-Pal, Marina; Susic, Edita; Dobrovic, Karolina; De Koster, Sien; Malhotra-Kumar, Surbhi; Tambic Andrasevic, Arjana

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Pristas, I., Ujevic, J., Bodulić, K., Andrijasevic, N., Bedenic, B., Payerl Pal, M. ... Tambic Andrasevic, A. (2024). The Association between Resistance and Virulence of Klebsiella pneumoniae in High-Risk Clonal Lineages ST86 and ST101. Microorganisms, 12. (10). doi: 10.3390/microorganisms12101997

Pristas, Irina, et al. "The Association between Resistance and Virulence of Klebsiella pneumoniae in High-Risk Clonal Lineages ST86 and ST101." Microorganisms, vol. 12, no. 10, 2024. https://doi.org/10.3390/microorganisms12101997

Pristas, Irina, Josip Ujevic, Kristian Bodulić, Natasa Andrijasevic, Branka Bedenic, Marina Payerl Pal, Edita Susic, et al. "The Association between Resistance and Virulence of Klebsiella pneumoniae in High-Risk Clonal Lineages ST86 and ST101." Microorganisms 12, no. 10 (2024). https://doi.org/10.3390/microorganisms12101997

Pristas, I., et al. (2024) 'The Association between Resistance and Virulence of Klebsiella pneumoniae in High-Risk Clonal Lineages ST86 and ST101', Microorganisms, 12(10). doi: 10.3390/microorganisms12101997

Pristas I, Ujevic J, Bodulić K, Andrijasevic N, Bedenic B, Payerl Pal M, and sur.. The Association between Resistance and Virulence of Klebsiella pneumoniae in High-Risk Clonal Lineages ST86 and ST101. Microorganisms [Internet]. 2024 September 30 [cited 2025 April 11];12(10). doi: 10.3390/microorganisms12101997

I. Pristas, et al., "The Association between Resistance and Virulence of Klebsiella pneumoniae in High-Risk Clonal Lineages ST86 and ST101", Microorganisms, vol. 12, no. 10, September 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:208907. [Accessed: 11 April 2025]

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Metadata
Title (english)The Association between Resistance and Virulence of Klebsiella pneumoniae in High-Risk Clonal Lineages ST86 and ST101
AuthorIrina Pristas
AuthorJosip Ujevic
AuthorKristian Bodulić
AuthorNatasa Andrijasevic
AuthorBranka Bedenic
AuthorMarina Payerl-Pal
AuthorEdita Susic
AuthorKarolina Dobrovic
AuthorSien De Koster
AuthorSurbhi Malhotra-Kumar
AuthorArjana Tambic Andrasevic
Author's institution(Dubrava University Hospital)
Author's institution(Sestre milosrdnice University Hospital Center)
Author's institution(Zagreb University Hispital Center)
Author's institution(University hospital for infectious diseases "Dr. Fran Mihaljević")
Author's institutionUniversity of Zagreb
School of Medicine
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Klebsiella pneumoniae is an opportunistic pathogen known for two main pathotypes: classical K. pneumoniae (cKp), often multidrug-resistant and common in hospitals, and hypervirulent K. pneumoniae (hvKp), associated with severe community-acquired infections. The recent emergence of strains combining hypervirulence and resistance is alarming. This study investigates the distribution of sequence types (STs), resistance, and virulence factors in K. pneumoniae strains causing bloodstream and urinary tract infections in Croatia. In 2022, 200 consecutive K. pneumoniae isolates were collected from blood and urine samples across several Croatian hospitals. Whole genome sequencing was performed on 194 isolates. Within the analyzed K. pneumoniae population, the distribution of sequence types was determined with multi-locus sequence typing (MLST) and capsule loci, resistance, and virulence determinants were assessed with the bioinformatics tool Kleborate. The analysis identified 77 different STs, with ST101 (24.6%) being the most prevalent, predominantly linked to the K17 capsular type (CT), invasive device usage, high antimicrobial resistance, and low virulence scores. The highest virulence scores were recorded in ST86 isolates, which were predominantly linked to the K2 CT and included some strains with medium resistance scores. String tests were positive in 19 strains, but only four of those harbored hypermucoviscous genetic determinants. The most prevalent ST101 clone in Croatia demonstrated a diverging association between resistance and virulence. An alarming co-existence of resistance and virulence was recorded in the ST86 strains.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMicroorganisms
Numberingvol. 12, no. 10, 1997
e-ISSN2076-2607
DOIhttps://doi.org/10.3390/microorganisms12101997
URN:NBNurn:nbn:hr:127:208907
Publication2024-09-30
Document URLhttps://www.mdpi.com/2076-2607/12/10/1997
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-03-05 11:27:16