prikaz prve stranice dokumenta Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges
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Scientific paper - Review paper
Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges
Applied Sciences, 14 (2024), 23; 11405. https://doi.org/10.3390/app142311405
Špiljak, Bruno; Ozretić, Petar; Andabak Rogulj, Ana; Lončar Brzak, Božana; Brailo, Vlaho; Škerlj, Marija; Vidović Juras, Danica

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Špiljak, B., Ozretić, P., Andabak Rogulj, A., Lončar Brzak, B., Brailo, V., Škerlj, M. & Vidović Juras, D. (2024). Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges. Applied Sciences, 14. (23). doi: 10.3390/app142311405

Špiljak, Bruno, et al. "Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges." Applied Sciences, vol. 14, no. 23, 2024. https://doi.org/10.3390/app142311405

Špiljak, Bruno, Petar Ozretić, Ana Andabak Rogulj, Božana Lončar Brzak, Vlaho Brailo, Marija Škerlj and Danica Vidović Juras. "Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges." Applied Sciences 14, no. 23 (2024). https://doi.org/10.3390/app142311405

Špiljak, B., et al. (2024) 'Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges', Applied Sciences, 14(23). doi: 10.3390/app142311405

Špiljak B, Ozretić P, Andabak Rogulj A, Lončar Brzak B, Brailo V, Škerlj M, and sur.. Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges. Applied Sciences [Internet]. 2024 December 07 [cited 2025 April 06];14(23). doi: 10.3390/app142311405

B. Špiljak, et al., "Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges", Applied Sciences, vol. 14, no. 23, December 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:427546. [Accessed: 06 April 2025]

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Metadata
Title (english)Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges
AuthorBruno Špiljak
AuthorPetar Ozretić
AuthorAna Andabak Rogulj
AuthorBožana Lončar Brzak
AuthorVlaho Brailo
AuthorMarija Škerlj
AuthorDanica Vidović Juras
Author's institutionRuđer Bošković Institute
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Abstract (english)
This study aims to evaluate the potential benefits and challenges of integrating oral microbiome research into the clinical management of oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC). The oral microbiome has gained significant attention for its role in the pathogenesis and progression of these conditions, with emerging evidence suggesting its value as a diagnostic and prognostic tool. By critically analyzing current evidence and methodological considerations, this manuscript examines whether microbiome analysis in biopsy samples can aid in the early detection, prognosis, and management of OPMD and OSCC. The complexity and dynamic nature of the oral microbiome require a multifaceted approach to fully understand its clinical utility. Based on this review, we conclude that studying the oral microbiome in this context holds significant promise but also faces notable challenges, including methodological variability and the need for standardization. Ultimately, this manuscript addresses the question, “Should such research be undertaken, given the intricate interactions of various factors and the inherent obstacles involved?”, and also emphasizes the importance of further research to optimize clinical applications and improve patient outcomes.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleApplied Sciences
Numberingvol. 14, no. 23, 11405
e-ISSN2076-3417
DOIhttps://doi.org/10.3390/app142311405
URN:NBNurn:nbn:hr:127:427546
Publication2024-12-07
Document URLhttps://www.mdpi.com/2076-3417/14/23/11405
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-03-05 11:03:28