Rehabilitacija pacijenta s medikamentoznom osteonekrozom potpunim protezama - prikaz slučaja

postgraduate specialist thesis

• Title (english): Rehabilitation of a patient with medication related osteonecrosis of the jaw with complete dentures - case report
• Author: Karla Sučević
• Mentor: Samir Čimić (mentor)
• Committee member: Robert Ćelić (predsjednik povjerenstva)
• Committee member: Samir Čimić (član povjerenstva)
• Committee member: Marko Granić (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; Zagreb
• Defense date and country: 2025-02-19, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine

Abstract

U danabnje vrijeme medikamentozna osteonekroza eljusti postala je relativno česta pojava. Prvi put je opisana 2003. godine, a povezana je s korištenjem lijekova (bisfosfonati, denosumab i dr.) čija je moguća nuspojava osteonekroza čeljusti. Iako je
medikamentozna osteonekroza opisana i u drugim kostima, događa se gotovo uvijek u čeljustima, što se tumači najvećom stopom aktivne remodelacije čeljusti u odnosu na druge kosti. Postoji više načina liječenja osteonekroze. S obzirom na zahvaćenost čeljusti
i zuba često postoji potreba protetske sanacije tih pacijenata. U tim slučajevima defekti koštanog i mekog tkiva nastali osteonekrozom i/ili kirurškim liječenjem otežavaju protetsku sanaciju. U slučaju mobilno-protetske terapije, preporučuje se meko podlaganje zaostalog defekta osteonekroze, a nakon završetka izrade potrebno je učestalo kontrolirati pacijenta jer je moguć ponovni nastanak osteonekroze iz dekubitusa uzrokovanih protezom.

Abstract (english)

Medication-Related Osteonecrosis of the Jaw (MRONJ) has become a relatively common occurrence. It was first described in 2003 and is associated with the use of drugs such as bisphosphonates or denosumab, whose side effects include osteonecrosis. Although the condition has also been described in other bones, MRONJ almost always occurs in the jaw bone due to its high rate of active bone remodeling. There are several ways to treat osteonecrosis. Given that the jaw and teeth are affected, patients often need prosthetic rehabilitation, which can be difficult due to bone and soft tissue defects caused by
osteonecrosis itself and/or surgical treatment. In cases of removable-prosthetic therapy, soft denture reline is recommended. The patient must be monitored frequently to prevent formation of decubital lesions which could lead to recurrent osteonecrosis.

• Keywords: potupna zubna proteza; nekroza kosti; bisfosfonati; denosumab
• Keywords (english): Denture Complete; Osteonecrosis; Bisphosphonates; Denosumab
• Language: croatian
• URN:NBN: urn:nbn:hr:127:239913
• Study programme: Title: Dental prosthetics; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni specijalist dentalne medicine (sveučilišni specijalist dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2025-03-05 09:00:21