Revizija smjernica za liječenje pacijenata s medikamentoznom osteonekrozom čeljusti

master's thesis

• Title (english): Revision of Guidelines for the Treatment of Patients with Medication-Related Osteonecrosis of the Jaw
• Author: Miroslav Pehar
• Mentor: Davor Brajdić (mentor)
• Committee member: Davor Brajdić (predsjednik povjerenstva)
• Committee member: Petar Đanić (član povjerenstva)
• Committee member: Ivan Salarić (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Department of Oral Surgery); Zagreb
• Defense date and country: 2024-12-19, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Oral Surgery

Abstract

Ovaj radi bavi se strategijama za liječenje pacijenata s medikamentoznom osteonekrozom čeljusti (MRONJ) i pacijentima koji su pod rizikom za njen razvoj. MRONJ je stanje koje se najčešće javlja kod pacijenata na terapiji antiresorptivnim ili antiangiogenim lijekovima. U prošlosti je ovo stanje bilo poznato pod nazivom osteonekroza čeljusti uzrokovana bisfosfonatima (BRONJ). Da bi se ovo stanje uspješno diferencijalno dijagnosticiralo, važno je znati kliničku te radiološku sliku pojedinog stadija bolesti. Ovo se stanje liječi ovisno o uznapredovalosti, odnosno njegovu stadiju. Blaži stadiji zahtijevaju bolju oralnu higijenu, ispiranje antimikrobnim sredstvima te antibiotsku terapiju. Za razliku od njih, kod progresivnijih stadija bolesti koriste se operativne metode, od kojih je najpoznatija segmentna resekcija.

Abstract (english)

This paper deals with strategies for the treatment of patients with drug-induced osteonecrosis of the jaw (MRONJ) and patients who are at risk for its development. MRONJ is a condition that most often occurs in patients on antiresorptive or
antiangiogenic therapy. In the past, this condition was known as bisphosphonate-induced osteonecrosis of the jaw (BRONJ). In order to successfully differentiate this condition, it is important to know the clinical and radiological picture of each stage of the disease. This condition is treated depending on the advancedness, that is its stage. Milder stages require better oral hygiene, rinsing with antimicrobial agents and antibiotic therapy. In contrast to them, in more progressive stages of the disease, operative methods are used, the best known of which is segmental resection.

• Keywords: osteonekroza; sredstva za očuvanje gustoće kosti; osteonekroza čeljusti uzrokovana bisfosfonatima; lijekovi za očuvanje gustoće kostiju; denosumab
• Keywords (english): Osteonecrosis; Bone Density Conservation Agents; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Denosumab
• Language: croatian
• URN:NBN: urn:nbn:hr:127:630250
• Study programme: Title: Integrated undergraduate and graduate university study of Dental Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor dentalne medicine (doktor dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-12-10 15:35:30