CX43 Expression in Colonic Adenomas and Surrounding Mucosa Is a Marker of Malignant Potential

Scientific paper - Original scientific paper

• Author: Alen Bišćanin
• Author: Neven Ljubičić
• Author: Marko Boban
• Author: Drinko Baličević
• Author: Ivana Pavić
• Author: Mirela Maver Bišćanin
• Author: Ivan Budimir
• Author: Zdravko Dorosulic
• Author: Marko Duvnjak
• Author's institution: (Sestre milosrdnice University Hospital Center)
• Author's institution: (Zagreb University Hispital Center)
• Author's institution: University of Zagreb; School of Medicine
• Author's institution: University of Zagreb; School of Dental Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine

Abstract (english)

Background/Aim: Colorectal cancer is a major public health problem. The adenoma-carcinoma sequence offers potential for screening and surveillance. We tested the clinical behavior and diagnostic utility of connexin 43 (CX43) in connection with pathohistological risk. Patients and Methods: Immunohistochemical expression of CX43 in colonic adenomas and surrounding mucosa from 87 patients was determined. Results: CX43 expression was higher in mucosa surrounding adenomas with high-grade dysplasia (p=0.047), larger adenomas (p=0.015) and villous adenomas (p=0.02). No difference of CX43 expression in adenomas according to grade of dysplasia was found (p=0.87). CX43 expression in adenomas was dependent on the patient's hemoglobin level (p=0.002), family history of colorectal cancer (p=0.009) and statin therapy (p=0.049). Conclusion: CX43 expression in mucosa surrounding adenoma could be an additional factor indicative of malignant potential. CX43 expression in colonic adenoma seems to be closely related to family history of colorectal cancer, statin therapy and hemoglobin level.

• Keywords (english): Colorectal cancer; CX43; Malignant potential of adenoma
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review - international
• Publication version: Published version
• Journal title: Anticancer Research
• Numbering: vol. 36, no. 10, pp. 5437-5442
• p-ISSN: 0250-7005
• e-ISSN: 1791-7530
• DOI: https://doi.org/10.21873/anticanres.11122
• URN:NBN: urn:nbn:hr:127:127405
• Publication: 2016-10-12
• Document URL: http://ar.iiarjournals.org/content/36/10/5437.abstract
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-10-30 08:59:03