The dental pulp – biology, pathology and regenerative potential

master's thesis

• Title (croatian): Zubna pulpa – biologija, patologija i regenerativni potencijal
• Author: Hendrik Benjamin Oellerich
• Mentor: Ivana Savić Pavičin (mentor)
• Committee member: Ivana Savić Pavičin (predsjednik povjerenstva)
• Committee member: Paris Simeon (član povjerenstva)
• Committee member: Jelena Dumančić (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; Zagreb
• Defense date and country: 2024-08-27, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine; Endodonics and Restorative Dentistry

Abstract

Today the field of endodontics has become an indispensable part of dentistry. The term endodontics is derived from the Greek words "endo", meaning inside and "odont", meaning tooth referring to treatments of pulp and root canal system located inside of the tooth. The current treatment gold standard in endodontics is root canal treatment including partial or total removal of the pulpal tissues followed by root canal obturation. New findings in the fields of genetics, tissue engineering and stem cell research give reason to believe that regeneration of the tissues which comprise the tooth pulp may be possible in the future. The aim of this thesis is to provide an overview of the research and therapeutic approaches of regenerative strategies in endodontics. Current research advances, discussion approaches and potential future clinical applications of these technologies in endodontics are presented. The reader is equipped with the relevant knowledge to understand the basics of anatomy, pathology, and regenerative treatment approaches in endodontics. The recent research advances regarding endodontic regenerative therapies documented in scientific literature are promising. However, the development of guidelines for the clinical application has so far failed due to the lack of sufficient successful patient trials as well as ethical and safety concerns. The technological complexity of such treatment approaches and the associated costs for regenerative endodontic interventions indicate clear obstacles to a timely and wide application of this desirable advance in endodontics.

Abstract (croatian)

Danas je područje endodoncije neizostavan dio stomatologije. Riječ endodoncija izvedena je iz grčkih riječi "endo", što znači 'unutar' i "odont", što znači 'zub'. Pojam se odnosi na tretmane liječenja pulpe i sustava korijenskih kanala koji se nalaze unutar zuba. Trenutno zlatni standard liječenja u endodonciji podrazumjeva liječenje korijenskih kanala uključujući djelomično ili potpuno uklanjanje pulpnog tkiva nakon čega slijedi obturacija odnosno punjenje korijenskih kanala. Nova otkrića i istraživanja iz područja genetike, tkivnog inženjerstvu te istraživanja matičnih stanica daju nadu za moguću regeneraciju tkiva koja čine zubnu pulpu u budućnosti. Cilj ovog rada je dati pregled istraživanja, terapijskih pristupa i regenerativnih strategija u endodonciji. Prikazan je trenutačni napredak u istraživanjima, značajne diskusije u tom području i potencijalna buduća klinička primjena ovih tehnologija u endodonciji. Čitatelj je opskrbljen relevantnim spoznajama bitnim za razumijevanje osnova anatomije, patologije i regenerativnih pristupa liječenju u endodonciji. Nedavna istraživanja u vezi s endodontskim regenerativnim terapijama dokumentirana u znanstvenoj literaturi obećavaju mnogo i vrlo su optimistična. Međutim, smjernice za kliničku primjenu nisu još uvijek dostupne zbog nedovoljnog broja uspješnih ispitivanja na pacijentima, kao i zbog etičkih i sigurnosnih pitanja. Tehnološka složenost takvih pristupa liječenja i povezani troškovi regenerativnih endodontskih intervencija ukazuju jasno na prepreke pravodobnoj i širokoj primjeni ovog poželjnog napretka u endodonciji.

• Keywords: Endodontics; Regenerative Endodontics; Tissue Engineering
• Keywords (croatian): endodoncija; regenerativna endodoncija; tkivni inženjering
• Language: english
• URN:NBN: urn:nbn:hr:127:955122
• Study programme: Title: Dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor dentalne medicine (doktor dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-07-09 18:30:53