Povezanost gornjih i donjih dišnih putova

master's thesis

• Title (english): The interaction between upper and lower airways
• Author: Ana Katana
• Mentor: Davor Vagić (mentor)
• Committee member: Davor Vagić (predsjednik povjerenstva)
• Committee member: Robert Trotić (član povjerenstva)
• Committee member: Goran Geber (član povjerenstva)
• Granter: University of Zagreb; School of Dental Medicine; (Chair of Otorhynolaringology); Zagreb
• Defense date and country: 2016-09-29, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Dental Medicine

Abstract

Utjecaj gornjih na donje dišne putove predmet je brojnih istraživanja tijekom
posljednjega stoljeća. Pojam ujedinjenih dišnih putova upućuje na njihovu
interakciju. Kao mogući mehanizmi te interakcije navode se nazobronhalni refleks,
postnazalno slijevanje i resorpcija medijatora u cirkulaciju s posljedičnim
djelovanjem na pluća. Nemogućnost disanja kroz nos otežava kondicioniranje zraka
što, također, dovodi do negativnog učinka na donje dišne puteve. Liječenje gornjih
dišnih putova ima velik utjecaj na liječenje bolesti donjih dišnih putova, osobito
astme u djece i odraslih.
Koncentracija IgE protutijela u ispirku, broj upalnih stanica i IgE pozitivnih stanica
značajno su viši u astmatičara. Koncentracija triptaze povezana je samo u astmatičara
s koncentracijom IgE protutijela i brojem IgE pozitivnih stanica.
U obje grupe ispitanika zbroj subjektivnih simptoma značajno se smanjuje nakon
terapije bez korelacije s objektivnim prametrima upale. Sukladno navedenim
rezultatima zaključak je da grupa astmatičara predstavlja posebnu grupu među
ispitanicima s kroničnim rinosinuitisom.

Abstract (english)

The impact of the upper airways on the lower airways has been a subject of extensive
research over the last century. The term united airways indicates their interaction.
The possible mechanisms of this interaction are nasobronchial reflex, postnasal drip
and resorption of inflammatory mediators in the circulation with a consequential
effect on the lungs. The inability to breathe through the nose makes conditioning of
the air difficult, which leads to a negative effect on the lower airways. The treatment
of the upper respiratory tract has a major impact on the treatment of diseases of the
lower respiratory tract, particularly asthma in children and adults.
The granulocyte activation markers and IgE in sinus lavages, and the inflammatory
and IgE + cells counts were significantly higher in the asthmatic. The tryptase
concentrations did not differ, but only in the asthmatics they correlated significantly
with the IgE concentrations and IgE+ cells count.
Subjective scores were decreased after therapy in both groups of patients and without
correlation with objective parameters of inflammation. In accordance with these
results conclusion is that asthmatic patients present a distinct subgroup among the
patients with chronic rhinosinusitis.

• Keywords: disanje; sinusitis; astma
• Keywords (english): respiratory mechanics; asthma
• Language: croatian
• URN:NBN: urn:nbn:hr:127:322782
• Study programme: Title: dental medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-11-22 11:25:05