Cutaneous Hyalohyphomycosis and Its Atypical Clinical Presentations in Immunosuppressed Patients

Scientific paper - Review paper

• Author: Nikola Ferara
• Author: Sanja Špoljar
• Author: Liborija Lugović-Mihić; MBZ: 215056
• Author: Ana Gverić Grginić
• Author: Violeta Rezo Vranješ
• Author: Iva Bešlić
• Author: Judita Perović
• Author: Tihana Regović Džombeta
• Author's institution: (Sestre milosrdnice University Hospital Center)
• Author's institution: University of Zagreb; School of Medicine
• Author's institution: University of Zagreb; School of Dental Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

There has been a substantial increase in the number of cases of invasive fungal infections worldwide, which is associated with a growing number of immunosuppressed patients and a rise in antifungal resistance. Some fungi that were previously considered harmless to humans have become emerging pathogens. One of them is Purpureocillium lilacinum, a ubiquitous filamentous fungus commonly found in the environment, especially in the air and soil. P. lilacinum belongs to a bigger group of hyaline fungi that cause hyalohyphomycosis, a fungal infection caused by fungi with colorless hyphae. Although this is a heterogeneous group of fungi, there are similarities regarding their ubiquity, ways of transmission, affected patients, and difficulties in diagnostics and treatment. In hyalohyphomycosis, the skin is one of the most affected organs, which is why the involvement of dermatologists is crucial for the initial assessment, since the timely recognition and early diagnosis of this condition can prevent life-threatening infections and death. In this review, we covered cutaneous hyalohyphomycosis caused by P. lilacinum and other fungi in the same group, including Fusarium, Penicilium, Scedosporium, Scopulariopsis, Acremonium, and Trichoderma genera.

• Keywords (english): cutaneous fungal infections; cutaneous hyalohyphomycosis; invasive fungal infections; immunosuppressed patients; Purpureocillium lilacinum; Fusarium; Acremonium; mycetoma; spectrum of cutaneous infections
• Language: english
• Publication type: Scientific paper - Review paper
• Publication status: Published
• Peer review: Peer review - international
• Publication version: Published version
• Journal title: Life
• Numbering: vol. 14, no. 1, 154
• e-ISSN: 2075-1729
• DOI: https://doi.org/10.3390/life14010154
• URN:NBN: urn:nbn:hr:127:327621
• Publication: 2024-01-21
• Document URL: https://www.mdpi.com/2075-1729/14/1/154
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-02-15 08:13:38